The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis

Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasi...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Human brain mapping Ročník 44; číslo 17; s. 5784 - 5794
Hlavní autori: Akbarian, Fahimeh, Rossi, Chiara, Costers, Lars, D'hooghe, Marie B., D'haeseleer, Miguel, Nagels, Guy, Van Schependom, Jeroen
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: San Antonio John Wiley & Sons, Inc 01.12.2023
Predmet:
Autoimmune diseases
Benzodiazepines
Biomarkers
Brain
Cognition
Cognitive ability
Cognitive load
Cortex (parietal)
Disease
Excitation
Eye movements
Inhibition (psychology)
Language
Magnetoencephalography
Measurement methods
Measurement techniques
Multiple sclerosis
Neurodegenerative diseases
Parkinson's disease
Power spectra
Prefrontal cortex
Scanners
Schizophrenia
Short term memory
Sleep
Spatial memory
Synaptic transmission
Finland
ISSN:1065-9471, 1097-0193, 1097-0193
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro‐ and/or magnetoencephalography rolls off, is a non‐invasive biomarker of the E/I ratio. A steeper roll‐off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting‐state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs ( p  = .01). In the sub‐cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS ( p  = .01) and healthy subjects ( p  = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.
AbstractList Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro‐ and/or magnetoencephalography rolls off, is a non‐invasive biomarker of the E/I ratio. A steeper roll‐off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting‐state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs ( p  = .01). In the sub‐cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS ( p  = .01) and healthy subjects ( p  = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro- and/or magnetoencephalography rolls off, is a non-invasive biomarker of the E/I ratio. A steeper roll-off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting-state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs (p = .01). In the sub-cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS (p = .01) and healthy subjects (p = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro- and/or magnetoencephalography rolls off, is a non-invasive biomarker of the E/I ratio. A steeper roll-off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting-state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs (p = .01). In the sub-cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS (p = .01) and healthy subjects (p = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro‐ and/or magnetoencephalography rolls off, is a non‐invasive biomarker of the E/I ratio. A steeper roll‐off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting‐state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs (p = .01). In the sub‐cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS (p = .01) and healthy subjects (p = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS. The 1/f slope enables us to pick up the inhibitory effect of benzodiazepines in people with multiple sclerosis (pwMS). Cognitively impaired pwMS also demonstrate a steeper 1/f slope, suggesting a decreased E/I ratio, and a stronger inhibition/weaker excitation when compared with cognitively preserved pwMS and healthy subjects.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro‐ and/or magnetoencephalography rolls off, is a non‐invasive biomarker of the E/I ratio. A steeper roll‐off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting‐state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs (p = .01). In the sub‐cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS (p = .01) and healthy subjects (p = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.
Author Costers, Lars
Nagels, Guy
D'hooghe, Marie B.
Van Schependom, Jeroen
Akbarian, Fahimeh
D'haeseleer, Miguel
Rossi, Chiara
AuthorAffiliation 5 Department of Neurology UZ Brussel Brussels Belgium
4 National MS Center Melsbroek Melsbroek Belgium
3 icometrix Leuven Belgium
1 Department of Electronics and Informatics (ETRO) Vrije Universiteit Brussel Brussels Belgium
2 AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium
6 St Edmund Hall University of Oxford Oxford UK
AuthorAffiliation_xml – name: 1 Department of Electronics and Informatics (ETRO) Vrije Universiteit Brussel Brussels Belgium
– name: 3 icometrix Leuven Belgium
– name: 2 AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium
– name: 4 National MS Center Melsbroek Melsbroek Belgium
– name: 5 Department of Neurology UZ Brussel Brussels Belgium
– name: 6 St Edmund Hall University of Oxford Oxford UK
Author_xml – sequence: 1
  givenname: Fahimeh
  orcidid: 0000-0002-1623-6005
  surname: Akbarian
  fullname: Akbarian, Fahimeh
  organization: Department of Electronics and Informatics (ETRO) Vrije Universiteit Brussel Brussels Belgium, AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium
– sequence: 2
  givenname: Chiara
  surname: Rossi
  fullname: Rossi, Chiara
  organization: Department of Electronics and Informatics (ETRO) Vrije Universiteit Brussel Brussels Belgium, AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium
– sequence: 3
  givenname: Lars
  surname: Costers
  fullname: Costers, Lars
  organization: AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium, icometrix Leuven Belgium
– sequence: 4
  givenname: Marie B.
  surname: D'hooghe
  fullname: D'hooghe, Marie B.
  organization: National MS Center Melsbroek Melsbroek Belgium
– sequence: 5
  givenname: Miguel
  surname: D'haeseleer
  fullname: D'haeseleer, Miguel
  organization: National MS Center Melsbroek Melsbroek Belgium, Department of Neurology UZ Brussel Brussels Belgium
– sequence: 6
  givenname: Guy
  surname: Nagels
  fullname: Nagels, Guy
  organization: AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium, Department of Neurology UZ Brussel Brussels Belgium, St Edmund Hall University of Oxford Oxford UK
– sequence: 7
  givenname: Jeroen
  surname: Van Schependom
  fullname: Van Schependom, Jeroen
  organization: Department of Electronics and Informatics (ETRO) Vrije Universiteit Brussel Brussels Belgium, AIMS Lab Center for Neurosciences, Vrije Universiteit Brussel Brussels Belgium
BookMark eNplUU1P3DAQtRCofLQH_oGlXsohrO1k7fhUVQjaSkhctmfLcca7po6d2skK_j1OWQ6lpxnNvHkz7805Og4xAEKXlFxTQthq1w3XjDeCH6EzSqSoCJX18ZLzdSUbQU_Rec6PhFC6JvQDOq0FF2zN5RkaNjvAeQQzJe1x9nEErDPWeNDpNyQcLYYn4yY9uRhWLuxc55YUp6WCdeixidtQanvAdg5mabqwxS7gYfaTG33hNx5SzC5_RCdW-wyfDvEC_bq73dz8qO4fvv-8-XZfmbqlUyWp7YFSYXvdMVFT1uhacgN9ZzsueautJcxK0xJNhG1ky3oKHQNgQkqmSX2Bvr7yjnM3QG8gLPLUmFyR9ayidurfTnA7tY17VRyjsiFNYfhyYEjxzwx5UoPLBrzXAeKcFWs5Y4SRdln2-R30Mc4pFH0F1TZ83dC6LqjVK8oUJ3ICq95cLQc4Xzar5Zeq_FL9_WWZuHo38Xb__9gXtNmipA
CitedBy_id crossref_primary_10_1080_25742442_2024_2395217
crossref_primary_10_1177_13524585241253777
crossref_primary_10_1007_s00540_025_03561_3
crossref_primary_10_31083_j_fbl2911386
Cites_doi 10.1016/j.dcn.2021.100931
10.1002/hbm.10062
10.1152/jn.00295.2022
10.1093/arclin/11.4.329
10.1001/archpsyc.1961.01710120031004
10.1177/13524585221125381
10.1523/JNEUROSCI.2332-14.2015
10.1038/nri3871
10.1523/JNEUROSCI.18-13-05026.1998
10.1212/WNL.33.11.1444
10.1101/2021.01.13.426522
10.1016/j.bpsc.2020.02.004
10.1152/jn.00470.2011
10.1098/rstb.2013.0162
10.1016/j.pnmrs.2011.06.001
10.1002/ana.22366
10.1038/s41467-021-22742-8
10.1016/j.jneumeth.2007.11.008
10.1186/1471-2377-12-55
10.1038/nrneurol.2015.222
10.1177/1352458509348519
10.1191/1352458504ms1098oa
10.1006/nimg.1995.1012
10.1016/j.biopsych.2021.02.637
10.1152/jn.00388.2019
10.1016/j.dcn.2020.100895
10.1016/j.neuroimage.2018.06.068
10.1177/1352458509106615
10.1016/j.neuropsychologia.2005.10.005
10.1016/j.neuroimage.2011.04.041
10.1007/s00401-020-02258-z
10.1037/1040-3590.8.2.145
10.1016/j.jns.2014.05.042
10.1101/113449
10.1155/2011/156869
10.1016/j.neuroimage.2005.02.008
10.1101/2021.10.15.464483
10.1016/j.jmr.2010.11.003
10.1371/journal.pcbi.1003263
10.1002/hbm.24737
10.1523/JNEUROSCI.5297-05.2006
10.1111/ejn.15774
10.1111/j.2517-6161.1995.tb02031.x
10.1109/TSP.2005.853302
10.1038/s41593-020-00744-x
10.1523/ENEURO.0094-22.2022
10.1016/j.neuroimage.2017.06.078
10.1146/annurev.ne.08.030185.000321
10.1038/nrn1648
10.1038/nrn3801
10.3389/fninf.2022.989262
10.1109/TAC.1974.1100705
10.1038/s41583-018-0053-9
10.1016/j.msard.2017.08.018
10.7554/eLife.43415
10.1038/s41467-018-05316-z
ContentType Journal Article
Copyright 2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
2023 The Authors. published by Wiley Periodicals LLC.
Copyright_xml – notice: 2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
– notice: 2023 The Authors. published by Wiley Periodicals LLC.
DBID AAYXX
CITATION
7QR
7TK
7U7
8FD
C1K
FR3
K9.
P64
7X8
5PM
DOI 10.1002/hbm.26476
DatabaseName CrossRef
Chemoreception Abstracts
Neurosciences Abstracts
Toxicology Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
Technology Research Database
Toxicology Abstracts
ProQuest Health & Medical Complete (Alumni)
Chemoreception Abstracts
Engineering Research Database
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic

Technology Research Database
Database_xml – sequence: 1
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
DocumentTitleAlternate Akbarian et al
EISSN 1097-0193
EndPage 5794
ExternalDocumentID PMC10619404
10_1002_hbm_26476
GeographicLocations Finland
GeographicLocations_xml – name: Finland
GrantInformation_xml – fundername: ;
– fundername: Genzyme‐Sanofi
– fundername: Belgian Charcot Foundation
GroupedDBID ---
.3N
.GA
.Y3
05W
0R~
10A
1L6
1OB
1OC
1ZS
24P
31~
3SF
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5VS
66C
702
7PT
7X7
8-0
8-1
8-3
8-4
8-5
8FI
8FJ
8UM
930
A03
AAESR
AAEVG
AAFWJ
AAMMB
AANHP
AAONW
AAYCA
AAYXX
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABIVO
ABJNI
ABPVW
ABUWG
ACBWZ
ACCMX
ACGFS
ACIWK
ACPOU
ACPRK
ACRPL
ACSCC
ACXQS
ACYXJ
ADBBV
ADEOM
ADIZJ
ADMGS
ADNMO
ADPDF
ADXAS
AEFGJ
AEIMD
AENEX
AFBPY
AFFHD
AFGKR
AFKRA
AFPKN
AFRAH
AFZJQ
AGQPQ
AGXDD
AHMBA
AIDQK
AIDYY
AIQQE
AIURR
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
ASPBG
ATUGU
AUFTA
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BENPR
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BY8
CCPQU
CITATION
CS3
D-E
D-F
DCZOG
DPXWK
DR1
DR2
DU5
EBD
EBS
EJD
EMOBN
F00
F01
F04
F5P
FEDTE
FYUFA
G-S
G.N
GAKWD
GNP
GODZA
GROUPED_DOAJ
H.T
H.X
HBH
HF~
HHY
HHZ
HMCUK
HVGLF
HZ~
IAO
IHR
ITC
IX1
J0M
JPC
KQQ
L7B
LAW
LC2
LC3
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M6M
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NNB
O66
O8X
O9-
OIG
OK1
OVD
OVEED
P2P
P2W
P2X
P4D
PALCI
PHGZM
PHGZT
PIMPY
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
RJQFR
ROL
RPM
RX1
RYL
SAMSI
SUPJJ
SV3
TEORI
UB1
UKHRP
V2E
W8V
W99
WBKPD
WIB
WIH
WIK
WIN
WJL
WNSPC
WOHZO
WQJ
WXSBR
WYISQ
XG1
XSW
XV2
ZZTAW
~IA
~WT
7QR
7TK
7U7
8FD
C1K
FR3
K9.
P64
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c381t-91fde117fdab273124a396cedbfb6968aff02f9c80a07f4982d1eb2ee27992a03
ISICitedReferencesCount 13
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001119157300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1065-9471
1097-0193
IngestDate Tue Nov 04 02:06:22 EST 2025
Fri Sep 05 06:06:53 EDT 2025
Sat Nov 29 14:48:47 EST 2025
Tue Nov 18 22:08:17 EST 2025
Sat Nov 29 02:25:01 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 17
Language English
License This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c381t-91fde117fdab273124a396cedbfb6968aff02f9c80a07f4982d1eb2ee27992a03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-1623-6005
OpenAccessLink http://dx.doi.org/10.1002/hbm.26476
PMID 37672569
PQID 2884654133
PQPubID 996345
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10619404
proquest_miscellaneous_2862202080
proquest_journals_2884654133
crossref_citationtrail_10_1002_hbm_26476
crossref_primary_10_1002_hbm_26476
PublicationCentury 2000
PublicationDate 2023-12-01
PublicationDateYYYYMMDD 2023-12-01
PublicationDate_xml – month: 12
  year: 2023
  text: 2023-12-01
  day: 01
PublicationDecade 2020
PublicationPlace San Antonio
PublicationPlace_xml – name: San Antonio
– name: Hoboken, USA
PublicationTitle Human brain mapping
PublicationYear 2023
Publisher John Wiley & Sons, Inc
Publisher_xml – name: John Wiley & Sons, Inc
References e_1_2_11_32_1
e_1_2_11_55_1
e_1_2_11_30_1
e_1_2_11_57_1
e_1_2_11_36_1
e_1_2_11_51_1
e_1_2_11_13_1
e_1_2_11_34_1
e_1_2_11_53_1
e_1_2_11_29_1
e_1_2_11_6_1
e_1_2_11_27_1
e_1_2_11_4_1
Benjamini Y. (e_1_2_11_9_1) 1995; 57
Chini M. (e_1_2_11_12_1) 2022; 17
e_1_2_11_48_1
e_1_2_11_2_1
Smith A. (e_1_2_11_50_1) 1968; 3
e_1_2_11_60_1
e_1_2_11_20_1
e_1_2_11_45_1
Jenkinson M. (e_1_2_11_23_1) 2005
e_1_2_11_47_1
e_1_2_11_24_1
e_1_2_11_41_1
e_1_2_11_62_1
e_1_2_11_8_1
e_1_2_11_22_1
e_1_2_11_43_1
e_1_2_11_17_1
e_1_2_11_15_1
e_1_2_11_59_1
e_1_2_11_38_1
e_1_2_11_19_1
Quinn A. J. (e_1_2_11_42_1) 2018; 28
e_1_2_11_10_1
e_1_2_11_31_1
e_1_2_11_56_1
e_1_2_11_58_1
e_1_2_11_14_1
e_1_2_11_35_1
e_1_2_11_52_1
e_1_2_11_33_1
e_1_2_11_54_1
e_1_2_11_7_1
e_1_2_11_28_1
e_1_2_11_5_1
e_1_2_11_26_1
e_1_2_11_3_1
e_1_2_11_49_1
e_1_2_11_61_1
e_1_2_11_21_1
e_1_2_11_44_1
e_1_2_11_46_1
e_1_2_11_25_1
e_1_2_11_40_1
e_1_2_11_18_1
e_1_2_11_16_1
e_1_2_11_37_1
e_1_2_11_39_1
Bowman A. W. A. A. (e_1_2_11_11_1) 2014
References_xml – volume-title: Eleventh Annual Meeting of the Organization for Human Brain Mapping
  year: 2005
  ident: e_1_2_11_23_1
– ident: e_1_2_11_37_1
  doi: 10.1016/j.dcn.2021.100931
– ident: e_1_2_11_49_1
  doi: 10.1002/hbm.10062
– ident: e_1_2_11_3_1
  doi: 10.1152/jn.00295.2022
– ident: e_1_2_11_45_1
  doi: 10.1093/arclin/11.4.329
– ident: e_1_2_11_5_1
  doi: 10.1001/archpsyc.1961.01710120031004
– ident: e_1_2_11_22_1
  doi: 10.1177/13524585221125381
– ident: e_1_2_11_58_1
  doi: 10.1523/JNEUROSCI.2332-14.2015
– ident: e_1_2_11_14_1
  doi: 10.1038/nri3871
– ident: e_1_2_11_25_1
  doi: 10.1523/JNEUROSCI.18-13-05026.1998
– ident: e_1_2_11_27_1
  doi: 10.1212/WNL.33.11.1444
– ident: e_1_2_11_60_1
  doi: 10.1101/2021.01.13.426522
– ident: e_1_2_11_32_1
  doi: 10.1016/j.bpsc.2020.02.004
– ident: e_1_2_11_4_1
  doi: 10.1152/jn.00470.2011
– volume-title: R package sm: Nonparametric smoothing methods (version 2.2‐5.4)
  year: 2014
  ident: e_1_2_11_11_1
– ident: e_1_2_11_35_1
  doi: 10.1098/rstb.2013.0162
– ident: e_1_2_11_41_1
  doi: 10.1016/j.pnmrs.2011.06.001
– ident: e_1_2_11_40_1
  doi: 10.1002/ana.22366
– ident: e_1_2_11_28_1
  doi: 10.1038/s41467-021-22742-8
– ident: e_1_2_11_33_1
  doi: 10.1016/j.jneumeth.2007.11.008
– ident: e_1_2_11_6_1
  doi: 10.1186/1471-2377-12-55
– ident: e_1_2_11_30_1
  doi: 10.1038/nrneurol.2015.222
– ident: e_1_2_11_38_1
  doi: 10.1177/1352458509348519
– ident: e_1_2_11_7_1
  doi: 10.1191/1352458504ms1098oa
– ident: e_1_2_11_31_1
  doi: 10.1006/nimg.1995.1012
– ident: e_1_2_11_43_1
  doi: 10.1016/j.biopsych.2021.02.637
– ident: e_1_2_11_44_1
  doi: 10.1152/jn.00388.2019
– ident: e_1_2_11_46_1
  doi: 10.1016/j.dcn.2020.100895
– ident: e_1_2_11_34_1
  doi: 10.1016/j.neuroimage.2018.06.068
– volume: 3
  start-page: 83
  year: 1968
  ident: e_1_2_11_50_1
  article-title: The symbol‐digit modalities test: A neuropsychological test of learning and other cerebral disorders
  publication-title: Learning Disorders
– ident: e_1_2_11_52_1
  doi: 10.1177/1352458509106615
– ident: e_1_2_11_55_1
  doi: 10.1016/j.neuropsychologia.2005.10.005
– ident: e_1_2_11_61_1
  doi: 10.1016/j.neuroimage.2011.04.041
– ident: e_1_2_11_62_1
  doi: 10.1007/s00401-020-02258-z
– ident: e_1_2_11_8_1
  doi: 10.1037/1040-3590.8.2.145
– ident: e_1_2_11_17_1
  doi: 10.1016/j.jns.2014.05.042
– ident: e_1_2_11_39_1
  doi: 10.1101/113449
– ident: e_1_2_11_36_1
  doi: 10.1155/2011/156869
– volume: 17
  year: 2022
  ident: e_1_2_11_12_1
  article-title: An increase of inhibition drives the developmental decorrelation of neural activity
  publication-title: eLife
– ident: e_1_2_11_24_1
  doi: 10.1016/j.neuroimage.2005.02.008
– ident: e_1_2_11_19_1
  doi: 10.1101/2021.10.15.464483
– ident: e_1_2_11_21_1
  doi: 10.1016/j.jmr.2010.11.003
– volume: 28
  start-page: 12
  year: 2018
  ident: e_1_2_11_42_1
  article-title: Task‐evoked dynamic network analysis through hidden Markov modeling
  publication-title: Frontiers in Neuroscience
– ident: e_1_2_11_48_1
  doi: 10.1371/journal.pcbi.1003263
– ident: e_1_2_11_56_1
  doi: 10.1002/hbm.24737
– ident: e_1_2_11_20_1
  doi: 10.1523/JNEUROSCI.5297-05.2006
– ident: e_1_2_11_59_1
  doi: 10.1111/ejn.15774
– volume: 57
  start-page: 289
  issue: 1
  year: 1995
  ident: e_1_2_11_9_1
  article-title: Controlling the false discovery rate: A practical and powerful approach to multiple testing
  publication-title: Journal of the Royal Statistical Society: Series B: Methodological
  doi: 10.1111/j.2517-6161.1995.tb02031.x
– ident: e_1_2_11_54_1
  doi: 10.1109/TSP.2005.853302
– ident: e_1_2_11_16_1
  doi: 10.1038/s41593-020-00744-x
– ident: e_1_2_11_26_1
  doi: 10.1523/ENEURO.0094-22.2022
– ident: e_1_2_11_18_1
  doi: 10.1016/j.neuroimage.2017.06.078
– ident: e_1_2_11_53_1
  doi: 10.1146/annurev.ne.08.030185.000321
– ident: e_1_2_11_29_1
  doi: 10.1038/nrn1648
– ident: e_1_2_11_51_1
  doi: 10.1038/nrn3801
– ident: e_1_2_11_47_1
  doi: 10.3389/fninf.2022.989262
– ident: e_1_2_11_2_1
  doi: 10.1109/TAC.1974.1100705
– ident: e_1_2_11_15_1
  doi: 10.1038/s41583-018-0053-9
– ident: e_1_2_11_13_1
  doi: 10.1016/j.msard.2017.08.018
– ident: e_1_2_11_10_1
  doi: 10.7554/eLife.43415
– ident: e_1_2_11_57_1
  doi: 10.1038/s41467-018-05316-z
SSID ssj0011501
Score 2.4949617
Snippet Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory...
SourceID pubmedcentral
proquest
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 5784
SubjectTerms Autoimmune diseases
Benzodiazepines
Biomarkers
Brain
Cognition
Cognitive ability
Cognitive load
Cortex (parietal)
Disease
Excitation
Eye movements
Inhibition (psychology)
Language
Magnetoencephalography
Measurement methods
Measurement techniques
Multiple sclerosis
Neurodegenerative diseases
Parkinson's disease
Power spectra
Prefrontal cortex
Scanners
Schizophrenia
Short term memory
Sleep
Spatial memory
Synaptic transmission
Title The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis
URI https://www.proquest.com/docview/2884654133
https://www.proquest.com/docview/2862202080
https://pubmed.ncbi.nlm.nih.gov/PMC10619404
Volume 44
WOSCitedRecordID wos001119157300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: DOA
  dateStart: 20200101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Health & Medical Collection (Proquest)
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: 7X7
  dateStart: 20210801
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: BENPR
  dateStart: 20210801
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: PIMPY
  dateStart: 20210801
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVWIB
  databaseName: Wiley Online Library Free Content
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: WIN
  dateStart: 19960101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
– providerCode: PRVWIB
  databaseName: Wiley Online Library Open Access
  customDbUrl:
  eissn: 1097-0193
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0011501
  issn: 1065-9471
  databaseCode: 24P
  dateStart: 20200101
  isFulltext: true
  titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6FiFeEGygFUZlEEVIU7fESWv7sdBVm9iqagxpPEVO6iwRbVKabir_kJ_FsZ1LyyoED7xYlWPVSs5n-_hcvoPQW94L7NAmvQ53udNxhZQdwbsCFl5IbEl8xgNfF5ugoxG7vubjWu1nkQtzN6VJwlYrPv-vooY-ELZKnf0HcZd_Ch3wG4QOLYgd2r8WvM6fVKn32TSdS1VLRhzOVCCO9gnIVZAzc8MscRLFvo7bOtRgyBPdiqAide4VNts4qeIPM5gVDtg4W9dujUfAV1UnYDrF_HBTAuqbD7dyY20diiieydIOfQnndGxc_7FYVJFDKv3EFHA7F5XPadAmNErTm0jmqUaxzCtH57YL4vwWB7IlOOheBChcWbsAJFOn5UjmfYpC1jalFYtt3NBIFnCla5sybEru2gHfpaas8r3Dw5DRRv7sCLREuoWg-7T_2RsPht752ehT2xnOv3dU9TLl5W87A4OkHdQgtMtZHTXGZxfjr6VHCxRvffkvXqdgubLIcTnjpm5UXXg2w3XX9J-rJ-hxfnHBfQO4p6gmk12010_EMp39wO-wDiXWPppd9PAij9jYQzOAIy7giDUcsciwwAaOOA1xBcfjCoxYgxEDGHEJRrwGRhwnuAAjLsH4DH0Znlx9PO3kJT46AaiKSzhqw4m0bRpOhA-KNCibwoHtQ0780Fe0TSIMLRLygFnCoqHLGZnY0idSEso5EZbzHNWTNJH7CLsTJqhkkkrXd21iMeXAFrInmSAWt7pN9L74uF7xWqoMy9QzzN3EAzl4Wg5N9KYcOjekL9sGHRQS8vLln3mEMUVQaDtOE70uH8OOrdxwIpHprRrTI0TVxrWaiG1ItpxMcb5vPkniSHO_KwsOdy33xZ9nf4keVevtANWXi1v5Cj0I7pZxtmihHXpNdctaqPHhZDS-bGljVCtH7S8cZNVt
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+spectral+slope+as+a+marker+of+excitation%2Finhibition+ratio+and+cognitive+functioning+in+multiple+sclerosis&rft.jtitle=Human+brain+mapping&rft.au=Akbarian%2C+Fahimeh&rft.au=Rossi%2C+Chiara&rft.au=Costers%2C+Lars&rft.au=D%27hooghe%2C+Marie+B&rft.date=2023-12-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1065-9471&rft.eissn=1097-0193&rft.volume=44&rft.issue=17&rft.spage=5784&rft.epage=5794&rft_id=info:doi/10.1002%2Fhbm.26476&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1065-9471&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1065-9471&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1065-9471&client=summon