The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis

Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasi...

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Vydáno v:Human brain mapping Ročník 44; číslo 17; s. 5784 - 5794
Hlavní autoři: Akbarian, Fahimeh, Rossi, Chiara, Costers, Lars, D'hooghe, Marie B., D'haeseleer, Miguel, Nagels, Guy, Van Schependom, Jeroen
Médium: Journal Article
Jazyk:angličtina
Vydáno: San Antonio John Wiley & Sons, Inc 01.12.2023
Témata:
Autoimmune diseases
Benzodiazepines
Biomarkers
Brain
Cognition
Cognitive ability
Cognitive load
Cortex (parietal)
Disease
Excitation
Eye movements
Inhibition (psychology)
Language
Magnetoencephalography
Measurement methods
Measurement techniques
Multiple sclerosis
Neurodegenerative diseases
Parkinson's disease
Power spectra
Prefrontal cortex
Scanners
Schizophrenia
Short term memory
Sleep
Spatial memory
Synaptic transmission
Finland
ISSN:1065-9471, 1097-0193, 1097-0193
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Popis
Shrnutí:Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro‐ and/or magnetoencephalography rolls off, is a non‐invasive biomarker of the E/I ratio. A steeper roll‐off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker for cognition. We recruited 44 healthy control subjects and 95 pwMS who underwent resting‐state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines (BZDs) compared to pwMS not receiving BZDs ( p  = .01). In the sub‐cohort of pwMS not treated with BZDs, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS ( p  = .01) and healthy subjects ( p  = .02). Furthermore, we observed a significant correlation between 1/f spectral slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. In this study, we highlighted the value of the spectral slope in MS by quantifying the effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS.
Bibliografie:ObjectType-Article-1
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ISSN:1065-9471
1097-0193
1097-0193
DOI:10.1002/hbm.26476