Second-Pandemic Strain of Vibrio cholerae from the Philadelphia Cholera Outbreak of 1849

A draft genome of a second-pandemic V. cholerae strain was reconstructed with the use of a museum specimen from a victim of the 1849 cholera outbreak in Philadelphia. This strain was found to be of the O1 classical biotype. Cholera is a diarrheal disease caused by colonization of the intestines by c...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 370; no. 4; pp. 334 - 340
Main Authors:	Devault, Alison M, Golding, G. Brian, Waglechner, Nicholas, Enk, Jacob M, Kuch, Melanie, Tien, Joseph H, Shi, Mang, Fisman, David N, Dhody, Anna N, Forrest, Stephen, Bos, Kirsten I, Earn, David J.D, Holmes, Edward C, Poinar, Hendrik N
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 23.01.2014
Series:	Brief Report
Subjects:	Bacterial diseases Bacterial Typing Techniques Biological and medical sciences Cholera Cholera - epidemiology Cholera - history Cholera - microbiology Cholera toxin DNA, Bacterial - isolation & purification DNA, Mitochondrial - analysis Evolution, Molecular General aspects Genome, Bacterial Genomes Genomic Islands Genomics History, 19th Century Human bacterial diseases Humans Infectious diseases Intestine Intestines - microbiology Intestines - pathology Male Medical sciences Next-generation sequencing Pandemics Pandemics - history Philadelphia - epidemiology Phylogeny Polymorphism, Single Nucleotide Sequence Analysis, DNA Single-nucleotide polymorphism Tropical bacterial diseases Vibrio cholerae Vibrio cholerae - classification Vibrio cholerae - genetics Vibrio cholerae - pathogenicity Virulence Virulence Factors - analysis Philadelphia Canada Infection Epidemic Medicine Vibrio cholerae Bacteriosis Bacteria Vibrionaceae Cholera
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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