Second-Pandemic Strain of Vibrio cholerae from the Philadelphia Cholera Outbreak of 1849

A draft genome of a second-pandemic V. cholerae strain was reconstructed with the use of a museum specimen from a victim of the 1849 cholera outbreak in Philadelphia. This strain was found to be of the O1 classical biotype. Cholera is a diarrheal disease caused by colonization of the intestines by c...

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Vydané v:	The New England journal of medicine Ročník 370; číslo 4; s. 334 - 340
Hlavní autori:	Devault, Alison M, Golding, G. Brian, Waglechner, Nicholas, Enk, Jacob M, Kuch, Melanie, Tien, Joseph H, Shi, Mang, Fisman, David N, Dhody, Anna N, Forrest, Stephen, Bos, Kirsten I, Earn, David J.D, Holmes, Edward C, Poinar, Hendrik N
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Waltham, MA Massachusetts Medical Society 23.01.2014
Edícia:	Brief Report
Predmet:	Bacterial diseases Bacterial Typing Techniques Biological and medical sciences Cholera Cholera - epidemiology Cholera - history Cholera - microbiology Cholera toxin DNA, Bacterial - isolation & purification DNA, Mitochondrial - analysis Evolution, Molecular General aspects Genome, Bacterial Genomes Genomic Islands Genomics History, 19th Century Human bacterial diseases Humans Infectious diseases Intestine Intestines - microbiology Intestines - pathology Male Medical sciences Next-generation sequencing Pandemics Pandemics - history Philadelphia - epidemiology Phylogeny Polymorphism, Single Nucleotide Sequence Analysis, DNA Single-nucleotide polymorphism Tropical bacterial diseases Vibrio cholerae Vibrio cholerae - classification Vibrio cholerae - genetics Vibrio cholerae - pathogenicity Virulence Virulence Factors - analysis Philadelphia Canada Infection Epidemic Medicine Vibrio cholerae Bacteriosis Bacteria Vibrionaceae Cholera
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	A draft genome of a second-pandemic V. cholerae strain was reconstructed with the use of a museum specimen from a victim of the 1849 cholera outbreak in Philadelphia. This strain was found to be of the O1 classical biotype. Cholera is a diarrheal disease caused by colonization of the intestines by cholera toxin–expressing strains of the waterborne enteric bacterium V. cholerae . An outbreak can arise suddenly, especially in vulnerable populations with compromised sanitation infrastructure, as in the devastating 2010 outbreak in Haiti. 1 In 2012 alone, V. cholerae infected 3 million to 4 million people, killing nearly 100,000. 2 Although all pathogenic V. cholerae strains possess a similar genomic backbone that may have facilitated adaptation to human intestinal mucosa, 3 , 4 the predominant pathogenic strain, serogroup O1, harbors two genetically distinct biotypes: classical and El Tor (for descriptions of these and . . .
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1308663