ERK1/2 in immune signalling

Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. More recently, studies have shown that ERK1/2 plays...

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Bibliographic Details
Published in:Biochemical Society transactions Vol. 50; no. 5; p. 1341
Main Authors: Lucas, Richard M, Luo, Lin, Stow, Jennifer L
Format: Journal Article
Language:English
Published: England 31.10.2022
Subjects:
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
Inflammation
MAP Kinase Signaling System
Phosphorylation
Signal Transduction
Toll-like receptors
receptor signalling
extracellular signal-regulated kinases
cytokines
innate immunity
inflammation
ISSN:1470-8752, 1470-8752
Online Access:Get more information
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Summary:Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. More recently, studies have shown that ERK1/2 plays an essential role downstream of immune receptors to elicit inflammatory gene expression in response to infection and cell or tissue damage. Much of this work has studied ERK1/2 activation in Toll-like receptor (TLR) pathways, providing mechanistic insights into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging research uncovering evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation.
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ISSN:1470-8752
1470-8752
DOI:10.1042/BST20220271