Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains poorly understood. We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5 to 18 tissues per patient) in prospect...

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Bibliographic Details

Published in:	Science translational medicine Vol. 15; no. 706; p. eabq0476
Main Authors:	DeWolf, Susan, Elhanati, Yuval, Nichols, Katherine, Waters, Nicholas R, Nguyen, Chi L, Slingerland, John B, Rodriguez, Natasia, Lyudovyk, Olga, Giardina, Paul A, Kousa, Anastasia I, Andrlová, Hana, Ceglia, Nick, Fei, Teng, Kappagantula, Rajya, Li, Yanyun, Aleynick, Nathan, Baez, Priscilla, Murali, Rajmohan, Hayashi, Akimasa, Lee, Nicole, Gipson, Brianna, Rangesa, Madhumitha, Katsamakis, Zoe, Dai, Anqi, Blouin, Amanda G, Arcila, Maria, Masilionis, Ignas, Chaligne, Ronan, Ponce, Doris M, Landau, Heather J, Politikos, Ioannis, Tamari, Roni, Hanash, Alan M, Jenq, Robert R, Giralt, Sergio A, Markey, Kate A, Zhang, Yanming, Perales, Miguel-Angel, Socci, Nicholas D, Greenbaum, Benjamin D, Iacobuzio-Donahue, Christine A, Hollmann, Travis J, van den Brink, Marcel R M, Peled, Jonathan U
Format:	Journal Article
Language:	English
Published:	United States 26.07.2023
Subjects:	Animals Graft vs Host Disease - pathology Hematopoietic Stem Cell Transplantation Humans Mice Receptors, Antigen, T-Cell T-Lymphocytes - pathology
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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