CBP and p300: HATs for different occasions

The transcriptional coactivators CREB binding protein (CBP) and p300 are key regulators of RNA polymerase II-mediated transcription. Genetic alterations in the genes encoding these regulatory proteins and their functional inactivation have been linked to human disease. Findings in patients, knockout...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 68; no. 6; pp. 1145 - 1155
Main Author:	Kalkhoven, Eric
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15.09.2004 Elsevier Science
Subjects:	Acetyltransferases - chemistry Acetyltransferases - metabolism Acetyltransferases - physiology Animals Biological and medical sciences Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology CREB binding protein (CBP) CREB-Binding Protein Disease Histone acetyltransferase Histone Acetyltransferases Humans Medical sciences Nuclear Proteins - chemistry Nuclear Proteins - metabolism Nuclear Proteins - physiology p300 p300-CBP Transcription Factors Pharmacology. Drug treatments Specificity Trans-Activators - chemistry Trans-Activators - metabolism Trans-Activators - physiology Transcription Factors CREB binding protein (CBP) Disease MLL PHD Histone acetyltransferase CBP RTS p300 MORF Specificity CREB FAT MOZ HAT Acyltransferases Binding protein Enzyme Transferases Pharmacology
ISSN:	0006-2952, 1873-2968
Online Access:	Get full text
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