Perspective: present pesticide discovery paradigms promote the evolution of resistance – learn from nature and prioritize multi‐target site inhibitor design

For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single targets for potential pesticides. There is also the claim that registration of s...

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Vydáno v:Pest management science Ročník 76; číslo 2; s. 421 - 425
Hlavní autor: Gressel, Jonathan
Médium: Journal Article
Jazyk:angličtina
Vydáno: Chichester, UK John Wiley & Sons, Ltd 01.02.2020
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Témata:
CAD
Computer aided design
Epidemiology
Evolution
fragment based discovery
genomics
industry
Inhibitors
mechanism of action
Mode of action
multi‐target‐site pesticides, natural product pesticides
Natural products
Organic chemistry
pesticide discovery
Pesticide toxicity
Pesticides
Pesticides - analysis
scaffold hopping
target site resistance
target site resistance
multi-target-site pesticides, natural product pesticides
scaffold hopping
computer aided design
fragment based discovery
pesticide discovery
ISSN:1526-498X, 1526-4998, 1526-4998
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Shrnutí:For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single targets for potential pesticides. There is also the claim that registration of single target inhibiting pesticides is simpler if the mode of action is known. Conversely, if one looks at the evolution of resistance from an epidemiological perspective to ascertain which pesticides have been the most recalcitrant to evolutionary forces, it is those that have multiple target sites of action. Non‐target‐site resistances can evolve to multi‐target‐site inhibitors, but these resistances can often be overcome by structural modification of the pesticide. Industry has looked at pest‐toxic natural products as pesticide leads, but seems to have abandoned those where they can find no single target of action. Perhaps nature has been intelligent and evolved many natural products that are synergistic multi‐target‐site inhibitors, and that is why natural compounds have been active for millennia? We should be learning from nature while combining new chemistry technologies with vast accrued databases and computer aided design allowing fragment‐based discovery and scaffold hopping to produce multi‐target site inhibitors instead of single target pesticides. © 2019 Society of Chemical Industry Pesticide discovery paradigm must be changed towards multi‐target‐site inhibitors to delay resistance.
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ISSN:1526-498X
1526-4998
1526-4998
DOI:10.1002/ps.5649