The PI3K/AKT signaling pathway in regulatory T‐cell development, stability, and function

The PI3K/AKT signaling pathway is an essential node in mammalian cells that controls cell growth, migration, proliferation, and metabolism. During the last decade, a number of works have demonstrated an important role for the PI3K/AKT pathway in regulatory T cell development, function, and stability...

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Bibliographic Details
Published in:Journal of leukocyte biology Vol. 103; no. 6; pp. 1065 - 1076
Main Authors: Pompura, Saige L., Dominguez‐Villar, Margarita
Format: Journal Article
Language:English
Published: England Oxford University Press 01.06.2018
Subjects:
1-Phosphatidylinositol 3-kinase
AKT
AKT protein
Cell migration
Cell proliferation
Foxp3
Lymphocytes
Lymphocytes T
Mammalian cells
PI3K
regulatory T cell
Signal transduction
Stability
Thymus
AKT
regulatory T cell
PI3K
Foxp3
ISSN:0741-5400, 1938-3673, 1938-3673
Online Access:Get full text
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Summary:The PI3K/AKT signaling pathway is an essential node in mammalian cells that controls cell growth, migration, proliferation, and metabolism. During the last decade, a number of works have demonstrated an important role for the PI3K/AKT pathway in regulatory T cell development, function, and stability. This review summarizes our current knowledge of how the PI3K/AKT pathway regulates thymic and peripheral Treg generation and function, with an emphasis on translation of these observations to therapies targeting Tregs in several pathologies. Review on the role of the PI3K/AKT pathway in regulatory T cell development and function, with a focus on pathologies associated with impaired PI3K signaling.
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ISSN:0741-5400
1938-3673
1938-3673
DOI:10.1002/JLB.2MIR0817-349R