13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

Naïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start to proliferate and generate effector cells to initiate a functional immune response. Metabolic reprogramming is essential to meet the biosynthetic demands of the differenti...

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Vydané v:	Frontiers in immunology Ročník 14; s. 1267816
Hlavní autori:	Kirchmair, Alexander, Nemati, Niloofar, Lamberti, Giorgia, Trefny, Marcel, Krogsdam, Anne, Siller, Anita, Hörtnagl, Paul, Schumacher, Petra, Sopper, Sieghart, Sandbichler, Adolf, Zippelius, Alfred, Ghesquière, Bart, Trajanoski, Zlatko
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Frontiers Media S.A 19.10.2023
Predmet:	13C tracer analysis differentiation exhaustion Immunology immunometabolism RNA sequencing stem cell memory cells
ISSN:	1664-3224, 1664-3224
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