Oncogenic transformation by the human polyomaviruses
The human polyomaviruses, BKV and JCV, were first isolated 30 years ago, BKV from the urine of a renal transplant patient (Gardner et al., 1971) and JCV from the brain of a patient with progressive multifocal leukoencephalopathy (PML) (Padgett et al., 1971), a neurodegenerative disease in which glia...
Uloženo v:
| Vydáno v: | Oncogene Ročník 20; číslo 54; s. 7917 - 7923 |
|---|---|
| Hlavní autor: | |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Nature Publishing Group
26.11.2001
|
| Témata: | |
| ISSN: | 0950-9232, 1476-5594 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Shrnutí: | The human polyomaviruses, BKV and JCV, were first isolated 30 years ago, BKV from the urine of a renal transplant patient (Gardner et al., 1971) and JCV from the brain of a patient with progressive multifocal leukoencephalopathy (PML) (Padgett et al., 1971), a neurodegenerative disease in which glial cells, the cells that produce myelin, are destroyed. These viruses share much in common with their well-studied simian cousin, SV40, but each also has its own unique features that distinguish it from the monkey virus. In this review, I will provide a brief overview of the biology of the two human viruses, an analysis of their transforming potential and their oncoproteins, the T antigens, and a discussion of the possible role of these viruses in human cancer. |
|---|---|
| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 |
| ISSN: | 0950-9232 1476-5594 |
| DOI: | 10.1038/sj.onc.1204916 |