Oncogenic transformation by the human polyomaviruses

The human polyomaviruses, BKV and JCV, were first isolated 30 years ago, BKV from the urine of a renal transplant patient (Gardner et al., 1971) and JCV from the brain of a patient with progressive multifocal leukoencephalopathy (PML) (Padgett et al., 1971), a neurodegenerative disease in which glia...

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Bibliographic Details
Published in:Oncogene Vol. 20; no. 54; pp. 7917 - 7923
Main Author: Imperiale, Michael J
Format: Journal Article
Language:English
Published: England Nature Publishing Group 26.11.2001
Subjects:
Amino acids
Antigens
Biology
BK virus
Cancer
Cell Transformation, Neoplastic
Cell Transformation, Viral
Human polyomavirus
Humans
Immunology
JC virus
oncogenes
Patients
Polyomavirus
Polyomavirus - physiology
Proteins
Viruses
Ann Arbor Michigan
United States > US
ISSN:0950-9232, 1476-5594
Online Access:Get full text
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Summary:The human polyomaviruses, BKV and JCV, were first isolated 30 years ago, BKV from the urine of a renal transplant patient (Gardner et al., 1971) and JCV from the brain of a patient with progressive multifocal leukoencephalopathy (PML) (Padgett et al., 1971), a neurodegenerative disease in which glial cells, the cells that produce myelin, are destroyed. These viruses share much in common with their well-studied simian cousin, SV40, but each also has its own unique features that distinguish it from the monkey virus. In this review, I will provide a brief overview of the biology of the two human viruses, an analysis of their transforming potential and their oncoproteins, the T antigens, and a discussion of the possible role of these viruses in human cancer.
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ISSN:0950-9232
1476-5594
DOI:10.1038/sj.onc.1204916