Preparation of Stable Zein/Poly(γ‐glutamic acid) Nanocomposite Particles for Improved Encapsulation of Curcumin

The aim of this study is to enhance the stability of zein nanoparticles by using poly(γ‐glutamic acid) (γ‐PGA) as a stabilizer. Zein/γ‐PGA nanocomposite particles are produced through a straightforward anti‐solvent precipitation method. The incorporation of γ‐PGA influenced the average particle size...

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Vydáno v:Advanced materials interfaces Ročník 12; číslo 13
Hlavní autoři: Mei, Jie, Li, Yunxing, Feng, Yikai, Zhao, Bingtian, Yang, Cheng, Sun, Yajuan, Ngai, To
Médium: Journal Article
Jazyk:angličtina
Vydáno: Weinheim John Wiley & Sons, Inc 01.07.2025
Wiley-VCH
Témata:
Cosmetics
Encapsulation
Fourier transforms
Glutamic acid
High temperature
Hydrophobicity
Infrared spectroscopy
nanocomposite particle
Nanocomposites
Nanoparticles
poly(γ‐glutamic acid)
polyphenol
Spectrum analysis
Stability
Zein
Zeta potential
ISSN:2196-7350, 2196-7350
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Shrnutí:The aim of this study is to enhance the stability of zein nanoparticles by using poly(γ‐glutamic acid) (γ‐PGA) as a stabilizer. Zein/γ‐PGA nanocomposite particles are produced through a straightforward anti‐solvent precipitation method. The incorporation of γ‐PGA influenced the average particle size, zeta potential, and overall stability of the resulting zein/γ‐PGA nanocomposite particles. These particles exhibit greater resistance to aggregation and sedimentation compared to zein nanoparticles across various environmental conditions, including a wide pH range (3.0–9.0), elevated temperatures (80 °C for 120 min), high ionic strength (1000 mm), and prolonged storage at 4 °C (up to 3 months). Fluorescence spectroscopy reveals significant interactions between zein and γ‐PGA. Fourier transform infrared spectroscopy and zeta potential measurements indicate that hydrogen bonding, hydrophobic interactions, and electrostatic attraction are the primary mechanisms driving these interactions. Importantly, the conditions for forming zein/γ‐PGA nanocomposite particles are effectively utilized to encapsulate a hydrophobic bioactive model (curcumin) with high encapsulation efficiency. The encapsulated curcumin demonstrates improved stability and an amorphous structure compared to free curcumin. Based on these results, zein/γ‐PGA nanocomposite particles can serve as a promising vehicle for hydrophobic active ingredients in food, pharmaceuticals, and cosmetics. Biocompatible zein/poly(γ‐glutamic acid) nanocomposite particles are developed to enhance the stability of zein nanoparticles, which demonstrate excellent stability under a variety of environmental conditions and effective thermal protection for the encapsulated actives.
Bibliografie:ObjectType-Article-1
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ISSN:2196-7350
2196-7350
DOI:10.1002/admi.202500362