Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

CUB domain-containing protein 1 (CDCP1) is an oncogenic orphan transmembrane receptor and a promising target for the detection and treatment of cancer. Extracellular proteolysis of CDCP1 by poorly defined mechanisms induces pro-metastatic signaling. We describe a new approach for the rapid identific...

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Vydané v:	Nature chemical biology Ročník 17; číslo 7; s. 776 - 783
Hlavní autori:	Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha K., Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward W., Hooper, John D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.07.2021 Nature Publishing Group
Predmet:	631/67 631/92/468 631/92/613 631/92/96 Animals Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Cancer Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cleavage Enzymes Humans Metastases Metastasis Mice Mice, Inbred NOD Mice, SCID Molecular Structure Peptide Hydrolases - analysis Peptide Hydrolases - metabolism Peptides Phosphonates Physiology Plasmin Prostate cancer Proteins Proteolysis Receptors Substrate Specificity Substrates Target detection Thrombolytic drugs U-Plasminogen activator Urokinase
ISSN:	1552-4450, 1552-4469, 1552-4469
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