Long-term improvement of retinal sensitivity after macular hole surgery over at least 9-year-old follow-up: a case series

Purpose To evaluate the correlations between anatomical and functional changes in idiopathic macular hole (IMH) surgery in long-term follow-up. Methods This is a prospective, interventional single centre case series. The final sample is formed by 14 eyes of 14 patients who had undergone IMH surgery...

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Published in:Graefe's archive for clinical and experimental ophthalmology Vol. 258; no. 8; pp. 1655 - 1662
Main Authors: Nicolai, Michele, Franceschi, Alessandro, De Turris, Serena, Rosati, Alessandro, Pelliccioni, Paolo, Pirani, Vittorio, Pasanisi, Pierangelo, Mariotti, Cesare
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020
Springer Nature B.V
Subjects:
Acuity
Angiography
Eye
Medicine
Medicine & Public Health
Microvasculature
Ophthalmology
Retina
Retinal Disorders
Statistical analysis
Surgery
Tomography
Macular hole
Microperimetry
MP-1
Long-term study
Macular hole surgery
Retinal sensitivity
ISSN:0721-832X, 1435-702X, 1435-702X
Online Access:Get full text
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Summary:Purpose To evaluate the correlations between anatomical and functional changes in idiopathic macular hole (IMH) surgery in long-term follow-up. Methods This is a prospective, interventional single centre case series. The final sample is formed by 14 eyes of 14 patients who had undergone IMH surgery in our institution between 2005 and 2009 and were still followed up in 2019. Reported data were pre- and post-operative best-corrected visual acuity (BCVA), retinal sensitivity and fixation stability values on MP-1 and structural macular features on spectral domain optical coherence tomography. Optical coherence tomography angiography (OCTA) was utilized to assess microvascular characteristics at the final visit. Only patients with a successful MH closure were enrolled, excluding eyes affected by other relevant pathologies. Results Mean BCVA improvement was significant after surgery ( t test, p value < 0.001) and presented a slight, not statistically significant raise, between the post-operative and long-term follow-up. Differently, mean retinal sensibility (dB) showed a highly statistically significant difference between pre-operative and post-operative ( t test, p value = .002) and post-operative and last follow-up ( p value < 0.001). In the long-term follow-up, subjects having integrity of the inner segment/outer segment (IS/OS) layer showed no statistically significant difference in BCVA compared with subjects with IS/OS discontinuity ( t test, p value = 0.72). OCTA parameters of the operated eye showed no statistical significance compared with the fellow eye. Conclusions In successfully closed MHs, retinal sensibility measured by microperimetry significatively increases after a long follow-up period even when BCVA remains stable or raises slightly. Vessel density organization tends to be quantitatively similar to fellow eye several years after surgery.
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ISSN:0721-832X
1435-702X
1435-702X
DOI:10.1007/s00417-020-04719-3