Protein patterns of brush-border fragments in congenital lactose malabsorption and in specific hypolactasia of the adult

Brush-border membrane proteins of the small-bowel mucosa were separated on polyacrylamide gels from intestinal biopsy specimens obtained from four children with congenital lactose malabsorption and from two adults with specific hypolactasia. In three patients with the congenital type of lactase defi...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 294; no. 19; p. 1030
Main Authors: Freiburghaus, A U, Schmitz, J, Schindler, M, Rotthauwe, H W, Kuitunen, P, Launiala, K, Hadorn, B
Format: Journal Article
Language:English
Published: United States 06.05.1976
Subjects:
Adult
Age Factors
Biopsy
Child, Preschool
Electrophoresis, Polyacrylamide Gel
Female
Galactosidases - analysis
Galactosidases - deficiency
Glucosidases - analysis
Humans
Intestinal Mucosa - enzymology
Intestine, Small
Lactose Intolerance - enzymology
Male
Sucrase - analysis
ISSN:0028-4793
Online Access:Get more information
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Summary:Brush-border membrane proteins of the small-bowel mucosa were separated on polyacrylamide gels from intestinal biopsy specimens obtained from four children with congenital lactose malabsorption and from two adults with specific hypolactasia. In three patients with the congenital type of lactase deficiency the protein band corresponding to brush-border lactase was reduced in intensity, but was never completely absent. No difference in gel patterns was detected when this pattern in congenital deficiency was compared to that obtained from the two patients with adult-type selective hypolactasia. In one patient with congenital lactose malabsorption the protein band corresponding to lactase activity was not detectable. The findings suggest that the mechanisms leading to low lactase activity in the congenital and adult forms of lactose intolerance are similar.
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ISSN:0028-4793
DOI:10.1056/NEJM197605062941903