Protein patterns of brush-border fragments in congenital lactose malabsorption and in specific hypolactasia of the adult

Brush-border membrane proteins of the small-bowel mucosa were separated on polyacrylamide gels from intestinal biopsy specimens obtained from four children with congenital lactose malabsorption and from two adults with specific hypolactasia. In three patients with the congenital type of lactase defi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The New England journal of medicine Ročník 294; číslo 19; s. 1030
Hlavní autoři: Freiburghaus, A U, Schmitz, J, Schindler, M, Rotthauwe, H W, Kuitunen, P, Launiala, K, Hadorn, B
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 06.05.1976
Témata:
Adult
Age Factors
Biopsy
Child, Preschool
Electrophoresis, Polyacrylamide Gel
Female
Galactosidases - analysis
Galactosidases - deficiency
Glucosidases - analysis
Humans
Intestinal Mucosa - enzymology
Intestine, Small
Lactose Intolerance - enzymology
Male
Sucrase - analysis
ISSN:0028-4793
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Brush-border membrane proteins of the small-bowel mucosa were separated on polyacrylamide gels from intestinal biopsy specimens obtained from four children with congenital lactose malabsorption and from two adults with specific hypolactasia. In three patients with the congenital type of lactase deficiency the protein band corresponding to brush-border lactase was reduced in intensity, but was never completely absent. No difference in gel patterns was detected when this pattern in congenital deficiency was compared to that obtained from the two patients with adult-type selective hypolactasia. In one patient with congenital lactose malabsorption the protein band corresponding to lactase activity was not detectable. The findings suggest that the mechanisms leading to low lactase activity in the congenital and adult forms of lactose intolerance are similar.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0028-4793
DOI:10.1056/NEJM197605062941903