The central vein sign helps in differentiating multiple sclerosis from its mimickers: lessons from Fabry disease

Objectives Although the use of specific MRI criteria has significantly increased the diagnostic accuracy of multiple sclerosis (MS), reaching a correct neuroradiological diagnosis remains a challenging task, and therefore the search for new imaging biomarkers is crucial. This study aims to evaluate...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:European radiology Ročník 32; číslo 6; s. 3846 - 3854
Hlavní autoři: Tranfa, Mario, Tortora, Mario, Pontillo, Giuseppe, Iuzzolino, Valentina, Riccio, Eleonora, Caccavallo, Simona, Di Risi, Teodolinda, Monti, Serena, Lanzillo, Roberta, Brescia Morra, Vincenzo, Palma, Giuseppe, Petracca, Maria, Pisani, Antonio, Brunetti, Arturo, Cocozza, Sirio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022
Springer Nature B.V
Témata:
Biomarkers
Criteria
Diagnosis
Diagnostic Radiology
Etiology
Fabry's disease
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Microvasculature
Multiple sclerosis
Neuroradiology
Radiology
Signs
Ultrasound
Magnetic resonance imaging
Fabry disease
Multiple sclerosis
ISSN:1432-1084, 0938-7994, 1432-1084
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Objectives Although the use of specific MRI criteria has significantly increased the diagnostic accuracy of multiple sclerosis (MS), reaching a correct neuroradiological diagnosis remains a challenging task, and therefore the search for new imaging biomarkers is crucial. This study aims to evaluate the incidence of one of the emerging neuroradiological signs highly suggestive of MS, the central vein sign (CVS), using data from Fabry disease (FD) patients as an index of microvascular disorder that could mimic MS. Methods In this retrospective study, after the application of inclusion and exclusion criteria, MRI scans of 36 FD patients and 73 relapsing–remitting (RR) MS patients were evaluated. Among the RRMS participants, 32 subjects with a disease duration inferior to 5 years (early MS) were also analyzed. For all subjects, a Fazekas score (FS) was recorded, excluding patients with FS = 0. Different neuroradiological signs, including CVS, were evaluated on FLAIR T2-weighted and spoiled gradient recalled echo sequences. Results Among all the recorded neuroradiological signs, the most striking difference was found for the CVS, with a detectable prevalence of 78.1% (57/73) in RRMS and of 71.4% (25/32) in early MS patients, while this sign was absent in FD (0/36). Conclusions Our results confirm the high incidence of CVS in MS, also in the early phases of the disease, while it seems to be absent in conditions with a different etiology. These results corroborate the possible role of CVS as a useful neuroradiological sign highly suggestive of MS. Key Points • The search for new imaging biomarkers is crucial to achieve a correct neuroradiological diagnosis of MS. • The CVS shows an incidence superior to 70% in MS patients, even in the early phases of the disease, while it appears to be absent in FD. • These findings further corroborate the possible future central role of CVS in distinguishing between MS and its mimickers.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1432-1084
0938-7994
1432-1084
DOI:10.1007/s00330-021-08487-4