Dural sinus collapsibility, idiopathic intracranial hypertension, and the pathogenesis of chronic migraine

Available evidences suggest that a number of known assumption on idiopathic intracranial hypertension (IIH) with or without papilledema might be discussed. These include (1) the primary pathogenetic role of an excessive dural sinus collapsibility in IIH, allowing a new relatively stable intracranial...

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Vydané v:Neurological sciences Ročník 40; číslo Suppl 1; s. 59 - 70
Hlavní autori: De Simone, Roberto, Ranieri, Angelo, Sansone, Mattia, Marano, Enrico, Russo, Cinzia Valeria, Saccà, Francesco, Bonavita, Vincenzo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Springer International Publishing 01.05.2019
Springer Nature B.V
Predmet:
Calcitonin gene-related peptide
Cortex
Headache
Hypertension
Innervation
Medicine
Medicine & Public Health
Migraine
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Optic nerve
Psychiatry
Review Article
Swelling
Therapeutic applications
Sinus stenosis
Chronic migraine
Bridge vein
Idiopathic intracranial hypertension
Self-limiting venous collapse
Starling resistor
ISSN:1590-1874, 1590-3478, 1590-3478
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Popis
Shrnutí:Available evidences suggest that a number of known assumption on idiopathic intracranial hypertension (IIH) with or without papilledema might be discussed. These include (1) the primary pathogenetic role of an excessive dural sinus collapsibility in IIH, allowing a new relatively stable intracranial fluids pressure balance at higher values; (2) the non-mandatory role of papilledema for a definite diagnosis; (3) the possibly much higher prevalence of IIH without papilledema than currently considered; (4) the crucial role of the cerebral compliance exhaustion that precede the raise in intracranial pressure and that may already be pathologic in cases showing a moderately elevated opening pressure; (5) the role as “intracranial pressure sensor” played by the trigeminovascular innervation of dural sinuses and cortical bridge veins, which could represent a major source of CGRP and may explain the high comorbidity and the emerging causative link between IIHWOP and chronic migraine (CM). Accordingly, the control of intracranial pressure is to be considered a promising new therapeutic target in CM.
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ISSN:1590-1874
1590-3478
1590-3478
DOI:10.1007/s10072-019-03775-w