Non-coding RNA in infantile hemangioma

Infantile hemangioma (IH) is the most common benign vascular tumor of infancy, but its pathogenesis has not been fully discovered. From the cellular perspective, CD133+ stem cells orchestrate the proliferation and development of IH. Regarding molecular mechanisms, hypoxia inducible factor-1α, renin-...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Pediatric research Ročník 96; číslo 7; s. 1594 - 1602
Hlavní autoři: Wang, Qizhang, Zhao, Chengzhi, Du, Qianxin, Cao, Zhiwei, Pan, Jian
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.12.2024
Nature Publishing Group
Témata:
Endocrine system
Gene Expression Regulation, Neoplastic
Growth factors
Hemangioma
Hemangioma - genetics
Humans
Hypoxia
Infant
Medicine
Medicine & Public Health
MicroRNAs - genetics
Pathogenesis
Pediatric Surgery
Pediatrics
Review Article
RNA, Long Noncoding - genetics
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Sarcoma
Stem cells
Veins & arteries
ISSN:0031-3998, 1530-0447, 1530-0447
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Infantile hemangioma (IH) is the most common benign vascular tumor of infancy, but its pathogenesis has not been fully discovered. From the cellular perspective, CD133+ stem cells orchestrate the proliferation and development of IH. Regarding molecular mechanisms, hypoxia inducible factor-1α, renin-angiotensin system, and vascular endothelial growth factor are current study hotspots, while non-coding RNAs (ncRNAs) might be essential factors participating in this network. Therefore, this article reviewed published studies concerning the roles of ncRNAs in IH and listed noted miRNAs, lncRNAs, and circRNAs. Other ncRNAs, such as snRNAs, snoRNAs, and tsRNAs, though have not been examined in IH, are mentioned as well to discuss their potential functions. Due to the continuous development of sequencing technologies and computational pipelines for ncRNAs annotation, relevant studies will provide evidence to gradually enhance acknowledgments of ncRNAs’ role in IH. The pathogenesis of IH might be revealed and the treatment protocol would be optimized in the future. Impact Non-coding RNAs (ncRNAs) play critical roles in infantile hemangioma. This article thoroughly reviewed all ncRNAs (miRNAs, lncRNAs, and circRNAs) mentioned in previous studies regarding the pathogenesis of infantile hemangioma. Other ncRNAs are promising subjects for further investigation. This review introduced the emerging ncRNAs that need to be explored in IH.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-024-03250-z