Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights

Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delv...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 397; no. 9; pp. 6317 - 6336
Main Authors:	Mangalpady, Shivaprasad Shetty, Peña-Corona, Sheila I., Borbolla-Jiménez, Fabiola, Kaverikana, Rajesh, Shetty, Shobhitha, Shet, Vinayaka Babu, Almarhoon, Zainab M., Calina, Daniela, Leyva-Gómez, Gerardo, Sharifi-Rad, Javad
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2024 Springer Nature B.V
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects Archives & records Asthma Biomedical and Life Sciences Biomedicine Breast cancer Breast carcinoma Cancer therapies Cell culture Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemistry Clinical trials Colon Colon cancer Colorectal cancer Cytotoxicity Dosage Herbal medicine Humans Infections Keywords Lactones - pharmacology Lactones - therapeutic use Medical Subject Headings-MeSH Metastases Metastasis Molecular modelling Nasopharyngeal carcinoma Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neurosciences Pharmacokinetics Pharmacology Pharmacology/Toxicology Pharmacy Prostate cancer Review Sesquiterpenes - pharmacokinetics Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction - drug effects Stat3 protein Throat cancer TOR protein Toxicity testing Tumor cell lines Anti-cancer mechanisms Sesquiterpene lactone, Src degradation PI3K/AKT/mTOR pathway Arnicolide D Apoptosis Centipeda minima
ISSN:	0028-1298, 1432-1912, 1432-1912
Online Access:	Get full text
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