Impact of Bariatric Surgery on Clinical, Biochemical, and Hormonal Parameters in Women with Polycystic Ovary Syndrome (PCOS)

There is limited data on the impact of bariatric surgery on polycystic ovarian syndrome (PCOS) especially in the Indian population. Background To study the impact of bariatric surgery in women with PCOS in terms of clinical, hormonal, and radiological aspects of polycystic ovarian syndrome. Methods...

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Vydáno v:Obesity surgery Ročník 30; číslo 6; s. 2294 - 2300
Hlavní autoři: Singh, Devender, Arumalla, Kirit, Aggarwal, Sandeep, Singla, Vitish, Ganie, Ashraf, Malhotra, Neena
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.06.2020
Springer Nature B.V
Témata:
Bariatric Surgery
Female
Gastrointestinal surgery
Hirsutism - etiology
Humans
Hyperandrogenism
Medicine
Medicine & Public Health
Menstruation
Obesity, Morbid - surgery
Original Contributions
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Surgery
Polycystic ovaries
PCOS
Bariatric surgery
ISSN:0960-8923, 1708-0428, 1708-0428
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Shrnutí:There is limited data on the impact of bariatric surgery on polycystic ovarian syndrome (PCOS) especially in the Indian population. Background To study the impact of bariatric surgery in women with PCOS in terms of clinical, hormonal, and radiological aspects of polycystic ovarian syndrome. Methods A prospective observational study of 50 women who underwent bariatric surgery at our tertiary care center. Evaluation of anthropometric data and menstrual cyclicity as well as markers of hyperandrogenism was done preoperatively and at 3- and 6-month and 1-year follow-up. Results Eighteen (36%) women were diagnosed to have PCOS. % EWL at 3-months ( n  = 14), 6-month ( n  = 14), and 1-year ( n  = 11) follow-up was 31%, 49%, and 63% respectively among women with PCOS. All females regained their normal menstrual cycle at 3 months of follow-up. Hirsutism resolved completely among 44% (5/11) with a decline in median hirsutism score from 11 to 9 at 1-year follow-up. Mean serum testosterone decreased from 0.83 ± 0.38 ng/ml preoperatively to 0.421 ± 0.25 ng/ml at 1-year follow-up ( p  ˂ 0.01), whereas changes in levels of serum LH and FSH were not significant. Seventy-seven percent of females (14/18) had polycystic ovaries preoperatively on USG; out of which, 55% (i.e., 4/7) showed complete resolution at 1-year follow-up. Metabolic syndrome resolved completely at 1-year follow-up in both PCOS and non PCOS group. Conclusions Bariatric surgery results in an effective and sustained weight loss with improvement in clinical, hormonal, and radiological parameters associated with PCOS.
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ISSN:0960-8923
1708-0428
1708-0428
DOI:10.1007/s11695-020-04487-3