Weight change and the risk of hip fractures in patients with type 2 diabetes: a nationwide cohort study

Summary Both weight gain and weight loss in type 2 diabetic population were associated with increased risk of hip fracture, while maintaining weight lowered the risk of hip fracture. Regarding the risk of hip fracture, we can propose active monitoring to maintain the weight of type 2 diabetes patien...

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Vydané v:Osteoporosis international Ročník 33; číslo 8; s. 1755 - 1767
Hlavní autori: Lee, S.-W., Han, K., Kwon, H.-S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Springer London 01.08.2022
Springer Nature B.V
Predmet:
Age
Body weight
Body weight gain
Body weight loss
Cohort analysis
Diabetes
Diabetes mellitus (non-insulin dependent)
Endocrinology
Exercise
Fractures
Hip
Medicine
Medicine & Public Health
Morbidity
Original Article
Orthopedics
Physical activity
Physical fitness
Physical training
Population
Rheumatology
Sex differences
Weight control
Type 2 diabetes
Hip fractures
Weight change
ISSN:0937-941X, 1433-2965, 1433-2965
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Shrnutí:Summary Both weight gain and weight loss in type 2 diabetic population were associated with increased risk of hip fracture, while maintaining weight lowered the risk of hip fracture. Regarding the risk of hip fracture, we can propose active monitoring to maintain the weight of type 2 diabetes patients. Introduction In type 2 diabetes, patients are often asked to control their weight in order to reduce their diabetic morbidity. The American Diabetes Association recommends that diabetic patients conduct high-intensity interventions for regulating diet, physical activity, and behavior to reduce weight, followed by long-term comprehensive weight maintenance programs. Although such weight control attempts are required in diabetic patients, there are few studies on the effect of weight change on hip fracture in this population. We aim to investigate the association between body weight change and the incidence of hip fracture in subjects with type 2 diabetes using large-scale, nationwide cohort data on the Korean population. Materials and methods A total of 1,447,579 subjects (894,204 men and 553,375 women) > 40 years of age, who were diagnosed with type 2 diabetes, were enrolled in this study. Weight change within 2 years was divided into five categories: from weight loss ≥ 10% to weight gain ≥ 10%. The hazard ratios (HRs) and 95% confidence intervals for the incidence of hip fracture were analyzed, compared with the reference of the stable weight group (weight change < 5%). Results Among 5 weight change groups, more than 10% weight loss showed the highest HR (HR, 1.605; 95% CI, 1.493 to 1.725), followed by more than 10% weight gain (HR, 1.457; 95% CI, 1.318 to 1.612). The effect of weight change on hip fracture risk was greater in males than in females, and those under 65 years of age were greater than those over 65 years of age. Baseline BMI did not play a role of weight change affecting the risk of hip fracture. The HR for hip fracture of subjects with regular exercise was lower than those without regular exercise. Conclusions In the type 2 diabetes population, both weight gain and weight loss were significantly associated with a higher risk of hip fracture, whereas maintaining body weight reduced the risk of hip fracture the most.
Bibliografia:ObjectType-Article-1
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ISSN:0937-941X
1433-2965
1433-2965
DOI:10.1007/s00198-022-06398-8