Combination of “quadratic adaptive algorithm” and “hybrid operator splitting” or uniformization algorithms for stability against acceleration in the Markov model of sodium ion channels in the ventricular cell model

The Markovian model has generally been used for cardiac electrophysiological simulations. However, the Markovian model is so stiff that speeding up the computation of the algorithms with variable time-steps always results in simulation instability. In particular, the unstable simulations always occu...

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