Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib

Purpose This study implements a physiologically based pharmacokinetic (PBPK) modelling approach to predict the effect of hydrastine and berberine, two major alkaloids present in goldenseal extract, on pharmacokinetics of imatinib and bosutinib. Methods PBPK models of hydrastine and berberine were de...

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Bibliographic Details
Published in:	European journal of clinical pharmacology Vol. 78; no. 4; pp. 597 - 611
Main Authors:	Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022 Springer Nature B.V
Subjects:	Aniline Compounds Antiretroviral drugs Berberine Biological Products Biomedical and Life Sciences Biomedicine Cyclosporins Cytochrome P-450 CYP3A - metabolism Digoxin Drug dosages Drug interaction Drug Interactions Enzymes Glycoproteins Humans Hydrastis - metabolism Hydrastis canadensis Imatinib Imatinib Mesylate Indinavir Inhibitor drugs Midazolam Models, Biological Natural products Nitriles P-Glycoprotein Pharmacokinetics Pharmacokinetics and Disposition Pharmacology/Toxicology Predictions Quinolines Berberine Imatinib Goldenseal Physiologically based pharmacokinetic Interactions Bosutinib
ISSN:	0031-6970, 1432-1041, 1432-1041
Online Access:	Get full text
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