Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment

The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and...

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Bibliographic Details
Published in:Clinical and experimental medicine Vol. 21; no. 2; pp. 205 - 213
Main Authors: Arab, Samaneh, Alizadeh, Akram, Asgharzade, Samira
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.05.2021
Springer Nature B.V
Subjects:
Adenosine
Apoptosis
Cancer
Cancer therapies
CD4 antigen
Cell activation
Cell proliferation
Hematology
Immune system
Immunological tolerance
Inflammation
Internal Medicine
Lymphocytes T
Medicine
Medicine & Public Health
Mesenchymal stem cells
Microenvironments
Oncology
PD-1 protein
PD-L1 protein
Phenotypes
Prostaglandin E2
Review Article
Stem cells
Tryptophan 2,3-dioxygenase
Adenosine
CD73
Cancer
Mesenchymal stem cells
ISSN:1591-8890, 1591-9528, 1591-9528
Online Access:Get full text
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Summary:The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical role in tumor growth and development. Investigating the mechanisms by which MSCs influence tumor growth and progression is very useful in establishing new therapeutic approaches. MSCs have some immunological capacities, including anti-inflammatory, immune-regulatory, and immune-suppressive abilities, which help the tumor growth in the inflammatory condition. They can suppress the proliferation and activation of CD4 + T cells and direct them toward the regulatory phenotype through the release of some factors such as indoleamine 2,3-dioxygenase, prostaglandin E2, and HO-1, PD-1 ligands (PD-L1 and PD-L2) and promote tolerance and apoptosis. Besides, these cells are able to produce adenosine. Adenosine has a key role in controlling the immune system by signaling through receptors located on the surface of immune cells. It plays a very essential role in tumor growth and progression. In the present review, we investigate and introduce adenosine-producing mesenchymal stem cells as a potential target for cancer treatment.
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ISSN:1591-8890
1591-9528
1591-9528
DOI:10.1007/s10238-020-00674-9