Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades

Patients undergoing radiation therapy experience debilitating side effects because of toxicity arising from radiation-induced DNA strand breaks in normal peritumoural cells. Here, inspired by the ability of tardigrades to resist extreme radiation through the expression of a damage-suppressor protein...

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Bibliographic Details

Published in:	Nature biomedical engineering Vol. 9; no. 8; p. 1240
Main Authors:	Kirtane, Ameya R, Bi, Jianling, Rajesh, Netra U, Tang, Chaoyang, Jimenez, Miguel, Witt, Emily, McGovern, Megan K, Cafi, Arielle B, Hatfield, Samual J, Rosenstock, Lauren, Becker, Sarah L, Machado, Nicole, Venkatachalam, Veena, Freitas, Dylan, Huang, Xisha, Chan, Alvin, Lopes, Aaron, Kim, Hyunjoon, Kim, Nayoon, Collins, Joy E, Howard, Michelle E, Manchkanti, Srija, Hong, Theodore S, Byrne, James D, Traverso, Giovanni
Format:	Journal Article
Language:	English
Published:	England 01.08.2025
Subjects:	Animals DNA Damage Humans Male Mice Nanoparticles - chemistry Radiation-Protective Agents RNA, Messenger - administration & dosage RNA, Messenger - genetics RNA, Messenger - metabolism Tardigrada - genetics Tardigrada - metabolism
ISSN:	2157-846X, 2157-846X
Online Access:	Get more information
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