Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades

Patients undergoing radiation therapy experience debilitating side effects because of toxicity arising from radiation-induced DNA strand breaks in normal peritumoural cells. Here, inspired by the ability of tardigrades to resist extreme radiation through the expression of a damage-suppressor protein...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature biomedical engineering Jg. 9; H. 8; S. 1240
Hauptverfasser:	Kirtane, Ameya R, Bi, Jianling, Rajesh, Netra U, Tang, Chaoyang, Jimenez, Miguel, Witt, Emily, McGovern, Megan K, Cafi, Arielle B, Hatfield, Samual J, Rosenstock, Lauren, Becker, Sarah L, Machado, Nicole, Venkatachalam, Veena, Freitas, Dylan, Huang, Xisha, Chan, Alvin, Lopes, Aaron, Kim, Hyunjoon, Kim, Nayoon, Collins, Joy E, Howard, Michelle E, Manchkanti, Srija, Hong, Theodore S, Byrne, James D, Traverso, Giovanni
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.08.2025
Schlagworte:	Animals DNA Damage Humans Male Mice Nanoparticles - chemistry Radiation-Protective Agents RNA, Messenger - administration & dosage RNA, Messenger - genetics RNA, Messenger - metabolism Tardigrada - genetics Tardigrada - metabolism
ISSN:	2157-846X, 2157-846X
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!