Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific target cell. In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory...

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Bibliographic Details

Published in:	The Journal of immunology (1950) Vol. 173; no. 2; p. 726
Main Authors:	Morales-Tirado, Vanessa, Johannson, Sara, Hanson, Elaine, Howell, Alan, Zhang, Jinyi, Siminovitch, Katherine A, Fowell, Deborah J
Format:	Journal Article
Language:	English
Published:	United States 15.07.2004
Subjects:	Animals CD4-Positive T-Lymphocytes - metabolism Chemokines - metabolism Cytokines - metabolism Mice Proteins - metabolism Staining and Labeling Wiskott-Aldrich Syndrome - metabolism Wiskott-Aldrich Syndrome Protein
ISSN:	0022-1767
Online Access:	Get more information
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