Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific target cell. In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory...

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Vydáno v:The Journal of immunology (1950) Ročník 173; číslo 2; s. 726
Hlavní autoři: Morales-Tirado, Vanessa, Johannson, Sara, Hanson, Elaine, Howell, Alan, Zhang, Jinyi, Siminovitch, Katherine A, Fowell, Deborah J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 15.07.2004
Témata:
Animals
CD4-Positive T-Lymphocytes - metabolism
Chemokines - metabolism
Cytokines - metabolism
Mice
Proteins - metabolism
Staining and Labeling
Wiskott-Aldrich Syndrome - metabolism
Wiskott-Aldrich Syndrome Protein
ISSN:0022-1767
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Shrnutí:The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific target cell. In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4(+) T cells. Murine WASp-deficient CD4(+) T cells fail to polarize cytokines toward a target and show an unexpected and striking block in cytokine secretion. In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. These results suggest that CD4(+) T cell cytokines require a specialized, WASp-dependent pathway for cellular traffic and/or vesicle release that is distinct from that required for chemokine release. We propose that the use of different secretory pathways for cytokines and chemokines enables CD4(+) T cell activity to be further fine-tuned to serve specialized effector functions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1767
DOI:10.4049/jimmunol.173.2.726