Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific target cell. In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory...

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Veröffentlicht in:	The Journal of immunology (1950) Jg. 173; H. 2; S. 726
Hauptverfasser:	Morales-Tirado, Vanessa, Johannson, Sara, Hanson, Elaine, Howell, Alan, Zhang, Jinyi, Siminovitch, Katherine A, Fowell, Deborah J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.07.2004
Schlagworte:	Animals CD4-Positive T-Lymphocytes - metabolism Chemokines - metabolism Cytokines - metabolism Mice Proteins - metabolism Staining and Labeling Wiskott-Aldrich Syndrome - metabolism Wiskott-Aldrich Syndrome Protein
ISSN:	0022-1767
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