Endometriosis-associated Ovarian Cancers

Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions...

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Bibliographic Details
Published in:Clinical obstetrics and gynecology Vol. 60; no. 4; p. 711
Main Authors: Anglesio, Michael S, Yong, Paul J
Format: Journal Article
Language:English
Published: United States 01.12.2017
Subjects:
Adenocarcinoma, Clear Cell - genetics
Adenocarcinoma, Clear Cell - pathology
Carcinoma, Endometrioid - genetics
Carcinoma, Endometrioid - pathology
Carcinoma, Ovarian Epithelial
Endometriosis - complications
Endometriosis - genetics
Endometriosis - pathology
Endometrium - pathology
Female
Humans
Mutation
Neoplasms, Glandular and Epithelial - genetics
Neoplasms, Glandular and Epithelial - pathology
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Ovary - pathology
ISSN:1532-5520, 1532-5520
Online Access:Get more information
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Summary:Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions are in fact the precursors for endometriosis-associated cancers. Herein, we will explore the relationship between endometriosis and ovarian carcinomas, similarities between the premalignant lesions and their cancerous counterparts, and the potential role of mutations and the ovarian microenvironment that may contribute to malignant transformation.
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ISSN:1532-5520
1532-5520
DOI:10.1097/GRF.0000000000000320