Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired deficiency of MHC expression. Low MHC-II expression defines tumors originating from the centroblast-rich dark zone of the g...

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Vydané v:	Cancer discovery Ročník 9; číslo 4; s. 546
Hlavní autori:	Ennishi, Daisuke, Takata, Katsuyoshi, Béguelin, Wendy, Duns, Gerben, Mottok, Anja, Farinha, Pedro, Bashashati, Ali, Saberi, Saeed, Boyle, Merrill, Meissner, Barbara, Ben-Neriah, Susana, Woolcock, Bruce W, Telenius, Adèle, Lai, Daniel, Teater, Matt, Kridel, Robert, Savage, Kerry J, Sehn, Laurie H, Morin, Ryan D, Marra, Marco A, Shah, Sohrab P, Connors, Joseph M, Gascoyne, Randy D, Scott, David W, Melnick, Ari M, Steidl, Christian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2019
Predmet:	Animals Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein - genetics Gene Expression Regulation, Neoplastic - genetics Humans Mice Prognosis
ISSN:	2159-8290, 2159-8290
On-line prístup:	Zistit podrobnosti o prístupe
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