Genome-Wide Association Analysis Identifies Loci for Powdery Mildew Resistance in Wheat

Wheat (Triticum aestivum L.), a staple crop of global significance, faces constant biotic stress threats, with powdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) being particularly damaging. In this study, a multi-year single-site experiment was conducted to minimize the environmental i...

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Veröffentlicht in:Agronomy (Basel) Jg. 15; H. 6; S. 1439
Hauptverfasser: Chen, Xiangdong, Wang, Haobo, Fang, Kaiqiang, Ding, Guohui, Dong, Nannan, Dong, Na, Zhang, Man, Zang, Yihao, Ru, Zhengang
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 01.06.2025
Schlagworte:
660K SNP array
Airborne microorganisms
Association analysis
Blumeria graminis f. sp. tritici
Cloning
Disease
Environmental impact
Gene mapping
Genes
Genomes
Genomic analysis
Genomics
Germplasm
GWAS
Haplotypes
Infections
Kinases
Leucine
Liu, Timothy
Pathogens
Powdery mildew
Protein kinases
Quantitative genetics
Quantitative trait loci
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Thioredoxin
Triticum aestivum L
Virulence
Wheat
China
Henan China
ISSN:2073-4395, 2073-4395
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Zusammenfassung:Wheat (Triticum aestivum L.), a staple crop of global significance, faces constant biotic stress threats, with powdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) being particularly damaging. In this study, a multi-year single-site experiment was conducted to minimize the environmental impacts, and a five-level classification system was used to assess powdery mildew resistance. A 660K SNP array genotyped 204 wheat germplasms, followed by GWAS. SNP loci with a −log10(p) > 3.0 were screened and validated across repeats to identify those associated with powdery mildew (Pm) resistance. Twelve SNPs were consistently associated with Pm resistance across multiple years. Of these, three colocalized with previously reported Pm-resistance gene or QTL regions, and the remaining nine represented potentially novel loci. The candidate genes identified included leucine-rich repeat (LRR) and NB-ARC immune receptors, as well as pathogen-related, thioredoxin, and serine threonine-protein kinase genes. Overall, the SNP loci and candidate genes identified in this study provide a basis for further fine mapping and cloning of the genes involved in relation to Pm resistance.
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ISSN:2073-4395
2073-4395
DOI:10.3390/agronomy15061439