Design of Multicatalytic Systems Through Self-Assembly

The development of self-assembled multicatalytic systems has emerged as a promising strategy for mimicking enzymatic catalysis in synthetic systems. This approach leverages the use of non-covalent interactions, such as hydrophobic interactions, hydrogen bonding, metal–ligand coordination, and aromat...

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Bibliographic Details
Published in:Catalysts Vol. 15; no. 3; p. 265
Main Authors: Fernandes, Antony E., Jonas, Alain M.
Format: Journal Article
Language:English
Published: Basel MDPI AG 01.03.2025
Subjects:
Amino acids
Catalysis
Chemical bonds
Chemical synthesis
Design
Design optimization
Efficiency
Enzymes
Flexibility
Hydrogen
Hydrogen bonding
Hydrophobicity
Modular design
Organic compounds
Self-assembly
Synthesis
ISSN:2073-4344, 2073-4344
Online Access:Get full text
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Summary:The development of self-assembled multicatalytic systems has emerged as a promising strategy for mimicking enzymatic catalysis in synthetic systems. This approach leverages the use of non-covalent interactions, such as hydrophobic interactions, hydrogen bonding, metal–ligand coordination, and aromatic stacking, to organize multiple catalytic centers within a defined, cooperative framework, allowing for enhanced reactivity, selectivity and efficiency, akin to the behavior of natural enzymes. The versatility of this approach enables the modular design, preparation, screening and optimization of systems capable of concerted catalysis and dynamic adaptation, making them suitable for a wide range of reactions, including asymmetric synthesis. The potential of these systems to emulate the precision and functionality of natural enzymes opens new avenues for the development of artificial multicatalytic systems with tailored and adaptable functions.
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ISSN:2073-4344
2073-4344
DOI:10.3390/catal15030265