Protective effect of Globularia alypum leaves against deltamethrin-induced nephrotoxicity in rats and determination of its bioactive compounds using high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry

•RP-HPLC-DAD-ESI-QTOF-MS/MS analysis of Globularia alypum extract was performed.•Thirty-nine compounds were identified and quantified.•Protective effect of G. alypum against deltamethrin induced nephrotoxicity was determined.•G. alypum reduces the DNA damage and fibrosis in the kidney. This study wa...

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Bibliographic Details
Published in:	Journal of functional foods Vol. 32; pp. 139 - 148
Main Authors:	Feriani, Anouar, del Mar Contreras, María, Talhaoui, Nassima, Gómez-Caravaca, Ana María, Taamalli, Amani, Segura-Carretero, Antonio, Ghazouani, Lakhdar, El Feki, Abdelfatteh, Allagui, Mohamed Salah
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.05.2017
Subjects:	Antioxidant antioxidants bioactive compounds chronic exposure creatinine Deltamethrin enzyme activity fibrosis Globularia alypum hemorrhage high performance liquid chromatography histopathology HPLC-DAD-ESI-QTOF-MS ionization leaf extracts leaves mass spectrometry necrosis Nephrotoxicity protective effect proximal tubules rats urea uric acid Globularia alypum HPLC-DAD-ESI-QTOF-MS Antioxidant Deltamethrin Nephrotoxicity
ISSN:	1756-4646, 2214-9414
Online Access:	Get full text
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