VEGF, ANGPT1, ANGPT2, and MMP-9 expression in the autologous hematopoietic stem cell transplantation and its impact on the time to engraftment
As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at ex...
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| Veröffentlicht in: | Annals of hematology Jg. 96; H. 12; S. 2103 - 2112 |
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| Sprache: | Englisch |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.12.2017
Springer Nature B.V |
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| ISSN: | 0939-5555, 1432-0584, 1432-0584 |
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| Abstract | As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplantation day (0) and 7 (+7), 14 (+14), and 21 (+21) days after HSCT. The cytokine levels were evaluated by ELISA method. Our study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. As opposite to ANGPT1, negative correlation between ANGPT2 level on day +7 after HSCT and the time to hematological recovery was noticed. Our study suggests that investigated cytokines are an important part of bone marrow environment and significantly influence the time to engraftment after HSCT. |
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| AbstractList | As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplantation day (0) and 7 (+7), 14 (+14), and 21 (+21) days after HSCT. The cytokine levels were evaluated by ELISA method. Our study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. As opposite to ANGPT1, negative correlation between ANGPT2 level on day +7 after HSCT and the time to hematological recovery was noticed. Our study suggests that investigated cytokines are an important part of bone marrow environment and significantly influence the time to engraftment after HSCT. As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplantation day (0) and 7 (+7), 14 (+14), and 21 (+21) days after HSCT. The cytokine levels were evaluated by ELISA method. Our study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. As opposite to ANGPT1, negative correlation between ANGPT2 level on day +7 after HSCT and the time to hematological recovery was noticed. Our study suggests that investigated cytokines are an important part of bone marrow environment and significantly influence the time to engraftment after HSCT.As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplantation day (0) and 7 (+7), 14 (+14), and 21 (+21) days after HSCT. The cytokine levels were evaluated by ELISA method. Our study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. As opposite to ANGPT1, negative correlation between ANGPT2 level on day +7 after HSCT and the time to hematological recovery was noticed. Our study suggests that investigated cytokines are an important part of bone marrow environment and significantly influence the time to engraftment after HSCT. |
| Author | Nowicki, Mateusz Małachowski, Roman Grzybowska-Izydorczyk, Olga Pluta, Agnieszka Robak, Tadeusz Wierzbowska, Agnieszka Szmigielska-Kapłon, Anna |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28956132$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1080_00071668_2021_1943309 crossref_primary_10_1002_jcp_30383 crossref_primary_10_3390_biology10070668 crossref_primary_10_3389_fbioe_2019_00370 crossref_primary_10_1186_s13578_025_01401_1 crossref_primary_10_1016_j_theriogenology_2022_03_028 crossref_primary_10_3389_fvets_2022_963759 crossref_primary_10_1016_j_cellsig_2020_109812 crossref_primary_10_1080_07357907_2024_2361295 crossref_primary_10_1111_ejh_13036 crossref_primary_10_1111_exd_14948 crossref_primary_10_1016_j_neuroscience_2020_03_027 crossref_primary_10_1002_sctm_20_0278 crossref_primary_10_1089_ten_tea_2019_0060 crossref_primary_10_1155_2018_2495848 |
| Cites_doi | 10.1242/jcs.01653 10.1002/jcb.24941 10.1111/ejh.12109 10.1016/j.bbmt.2014.04.030 10.1038/nm.2537 10.1371/journal.pone.0119857 10.1172/JCI44562 10.4103/0973-1482.146086 10.1084/jem.193.9.1005 10.1038/7434 10.1101/cshperspect.a006502 10.21037/sci.2016.06.07 10.1007/s12185-014-1583-1 10.1016/S0092-8674(00)00025-8 10.1038/sj.bmt.1705410 10.1016/j.ccr.2011.02.005 10.1371/journal.pone.0030758 10.1016/j.pharmthera.2016.06.001 10.1038/sj.leu.2403331 10.1016/j.cellsig.2009.11.007 10.1152/physiol.00025.2005 10.1215/S1152851705000232 10.1016/S0092-8674(02)00754-7 10.1016/j.ccr.2008.01.034 10.1172/JCI58196 10.1182/blood.V98.5.1289 10.1182/blood-2004-06-2480 10.1371/journal.pone.0039796 10.1016/j.canlet.2014.09.035 10.1016/j.cell.2004.07.004 10.20892/j.issn.2095-3941.2015.0070 10.1038/bmt.2012.101 10.1073/pnas.172161899 10.1631/jzus.B1201004 10.1038/359843a0 10.1126/science.284.5422.1994 10.1161/01.RES.0000063422.38690.DC 10.1007/s00277-013-1759-4 10.1016/j.matbio.2015.04.004 10.1126/science.272.5258.60 10.1007/s002770000236 10.1054/bjoc.2000.1437 10.7554/eLife.05521 10.1155/2015/786790 10.1152/ajpheart.2000.279.2.H817 |
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| Keywords | Engraftment Angiopoietin MMP-9 VEGF Hematopoietic stem cell transplantation (HSCT) |
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| References | Scharpfenecker, Fiedler, Reiss, Augustin (CR43) 2005; 118 Asada, Katayama (CR4) 2012; 99 Mazzieri, Pucci, Moi (CR16) 2011; 19 Sun, Zhang, Bi (CR19) 2016; 8 Gencheva, Hare, Kurian (CR39) 2013; 90 Butcher, Picker (CR35) 1996; 272 Koehne, Willam, Strauss, Schindler, Eckardt, Bührer (CR37) 2000; 279 Hattori, Dias, Heissig (CR41) 2001; 193 Sezer, Niemoller, Eucker (CR9) 2000; 79 Arai, Hirao, Ohmura (CR18) 2004; 118 Welford, Biziato, Coffelt (CR30) 2011; 121 Sinnathamby, Yun, Clavet-Lanthier (CR44) 2015; 116 Takahashi, Kalka, Masuda (CR2) 1999; 5 Biel, Siemann (CR5) 2016; 380 Kopp, Avecilla, Hooper, Rafii (CR1) 2005; 20 Falcon, Chintharlapalli, Uhlik, Pytowski (CR10) 2016; 164 Rellick, O'Leary, Piktel (CR38) 2012; 7 Liu, Chen, Chen (CR24) 2012; 13 Zub, Sousa, Sarno (CR12) 2015; 10 Hughes, Marron, Brindle (CR25) 2003; 92 Hayes, Huang, Yu, Maisonpierre (CR46) 2000; 83 Szmigielska-Kaplon, Krawczynska, Czemerska (CR7) 2013; 92 Saharinen, Alitalo (CR21) 2011; 121 Vande Broek, Asosingh, Allegaert (CR31) 2004; 18 Hansen, Singh, Tahir, Brindle (CR42) 2010; 22 Min, Kim, Lee (CR40) 2006; 38 Ueda, Chihara, Kohno (CR27) 2014; 20 Jiang, Sun, Quan (CR11) 2016; 12 Koch, Claesson-Welsh (CR15) 2012; 2 Saulle, Guerriero, Petronelli (CR23) 2012; 7 Lobov, Brooks, Lang (CR29) 2002; 99 Heissig, Hattori, Dias (CR34) 2002; 109 Yang, Wenlu, He, Zhang, Yue, Chai (CR8) 2015; 2015 Stoeltzing, Ahmad, Liu (CR47) 2003; 63 Zhou, Ding, Morrison (CR20) 2015; 4 Testa, Saulle, Castelli, Pelosi (CR6) 2016; 3 Weis, Cheresh (CR33) 2011; 17 Lévesque, Takamatsu, Nilsson, Haylock, Simmons (CR36) 2001; 98 Taichman (CR3) 2005; 105 Li, Zhao, Ren (CR14) 2016; 13 Shweiki, Itin, Soffer, Keshet (CR13) 1992; 359 Bergers, Song (CR26) 2005; 7 Holash, Maisonpierre, Compton (CR45) 1999; 284 Takakura, Watanabe, Suenobu (CR22) 2000; 102 Porkholm, Bono, Saarinen-Pihkala, Kivivuori (CR17) 2013; 48 Du, Lu, Petritsch (CR28) 2008; 13 Deryugina, Quigley (CR32) 2015; 44-46 S Koch (3133_CR15) 2012; 2 J Holash (3133_CR45) 1999; 284 AF Welford (3133_CR30) 2011; 121 JP Lévesque (3133_CR36) 2001; 98 I Vande Broek (3133_CR31) 2004; 18 RS Taichman (3133_CR3) 2005; 105 EI Deryugina (3133_CR32) 2015; 44-46 EC Butcher (3133_CR35) 1996; 272 KA Zub (3133_CR12) 2015; 10 E Saulle (3133_CR23) 2012; 7 DP Hughes (3133_CR25) 2003; 92 NM Biel (3133_CR5) 2016; 380 L Sun (3133_CR19) 2016; 8 SL Rellick (3133_CR38) 2012; 7 P Koehne (3133_CR37) 2000; 279 A Szmigielska-Kaplon (3133_CR7) 2013; 92 BL Falcon (3133_CR10) 2016; 164 F Arai (3133_CR18) 2004; 118 TM Hansen (3133_CR42) 2010; 22 O Stoeltzing (3133_CR47) 2003; 63 IB Lobov (3133_CR29) 2002; 99 HG Kopp (3133_CR1) 2005; 20 BO Zhou (3133_CR20) 2015; 4 G Bergers (3133_CR26) 2005; 7 U Testa (3133_CR6) 2016; 3 SM Weis (3133_CR33) 2011; 17 YL Li (3133_CR14) 2016; 13 N Takakura (3133_CR22) 2000; 102 M Scharpfenecker (3133_CR43) 2005; 118 T Takahashi (3133_CR2) 1999; 5 O Sezer (3133_CR9) 2000; 79 N Ueda (3133_CR27) 2014; 20 P Saharinen (3133_CR21) 2011; 121 R Du (3133_CR28) 2008; 13 N Asada (3133_CR4) 2012; 99 J Yang (3133_CR8) 2015; 2015 XB Liu (3133_CR24) 2012; 13 B Heissig (3133_CR34) 2002; 109 T Sinnathamby (3133_CR44) 2015; 116 D Shweiki (3133_CR13) 1992; 359 L Jiang (3133_CR11) 2016; 12 M Porkholm (3133_CR17) 2013; 48 R Mazzieri (3133_CR16) 2011; 19 K Hattori (3133_CR41) 2001; 193 CK Min (3133_CR40) 2006; 38 M Gencheva (3133_CR39) 2013; 90 AJ Hayes (3133_CR46) 2000; 83 |
| References_xml | – volume: 118 start-page: 771 issue: Pt 4 year: 2005 end-page: 780 ident: CR43 article-title: The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism publication-title: J Cell Sci doi: 10.1242/jcs.01653 – volume: 116 start-page: 45 issue: 1 year: 2015 end-page: 57 ident: CR44 article-title: VEGF and angiopoietins promote inflammatory cell recruitment and mature blood vessel formation in murine sponge/Matrigel model publication-title: J Cell Biochem doi: 10.1002/jcb.24941 – volume: 90 start-page: 469 issue: 6 year: 2013 end-page: 478 ident: CR39 article-title: Bone marrow osteoblast vulnerability to chemotherapy publication-title: Eur J Haematol doi: 10.1111/ejh.12109 – volume: 2015 start-page: 786790 year: 2015 ident: CR8 article-title: VEGF overexpression is a valuable prognostic factor for non-Hodgkin’s lymphoma evidence from a systemic meta-analysis publication-title: Dis Markers – volume: 20 start-page: 1335 issue: 9 year: 2014 end-page: 1340 ident: CR27 article-title: Predictive value of circulating angiopoietin-2 for endothelial damage-related complications in allogeneic hematopoietic stem cell transplantation publication-title: Biol Blood Marrow Transplant doi: 10.1016/j.bbmt.2014.04.030 – volume: 17 start-page: 1359 issue: 11 year: 2011 end-page: 1370 ident: CR33 article-title: Tumor angiogenesis: molecular pathways and therapeutic targets publication-title: Nat Med doi: 10.1038/nm.2537 – volume: 10 start-page: e0119857 issue: 3 year: 2015 ident: CR12 article-title: Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells publication-title: PLoS One doi: 10.1371/journal.pone.0119857 – volume: 121 start-page: 1969 issue: 5 year: 2011 end-page: 1973 ident: CR30 article-title: TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice publication-title: J Clin Invest doi: 10.1172/JCI44562 – volume: 12 start-page: 605 issue: 2 year: 2016 end-page: 611 ident: CR11 article-title: Abnormal vascular endothelial growth factor protein expression may be correlated with poor prognosis in diffuse large B-cell lymphoma: a meta-analysis publication-title: J Cancer Res Ther doi: 10.4103/0973-1482.146086 – volume: 193 start-page: 1005 issue: 9 year: 2001 end-page: 1014 ident: CR41 article-title: Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells publication-title: J Exp Med doi: 10.1084/jem.193.9.1005 – volume: 5 start-page: 434 issue: 4 year: 1999 end-page: 438 ident: CR2 article-title: Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization publication-title: Nat Med doi: 10.1038/7434 – volume: 2 start-page: a006502 issue: 7 year: 2012 ident: CR15 article-title: Signal transduction by vascular endothelial growth factor receptors publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006502 – volume: 3 start-page: 26 year: 2016 ident: CR6 article-title: Endothelial progenitor cells in hematologic malignancies publication-title: Stem Cell Investig doi: 10.21037/sci.2016.06.07 – volume: 99 start-page: 679 issue: 6 year: 2012 end-page: 684 ident: CR4 article-title: Regulation of hematopoiesis in endosteal microenvironments publication-title: Int J Hematol doi: 10.1007/s12185-014-1583-1 – volume: 102 start-page: 199 issue: 2 year: 2000 end-page: 209 ident: CR22 article-title: A role for hematopoietic stem cells in promoting angiogenesis publication-title: Cell doi: 10.1016/S0092-8674(00)00025-8 – volume: 38 start-page: 149 issue: 2 year: 2006 end-page: 156 ident: CR40 article-title: Vascular endothelial growth factor (VEGF) is associated with reduced severity of acute graft-versus-host disease and nonrelapse mortality after allogeneic stem cell transplantation publication-title: Bone Marrow Transplant doi: 10.1038/sj.bmt.1705410 – volume: 19 start-page: 512 issue: 4 year: 2011 end-page: 526 ident: CR16 article-title: Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.02.005 – volume: 7 start-page: e30758 issue: 2 year: 2012 ident: CR38 article-title: Bone marrow osteoblast damage by chemotherapeutic agents publication-title: PLoS One doi: 10.1371/journal.pone.0030758 – volume: 164 start-page: 204 year: 2016 end-page: 225 ident: CR10 article-title: Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2016.06.001 – volume: 18 start-page: 976 issue: 5 year: 2004 end-page: 982 ident: CR31 article-title: Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor publication-title: Leukemia doi: 10.1038/sj.leu.2403331 – volume: 63 start-page: 3370 issue: 12 year: 2003 end-page: 3377 ident: CR47 article-title: Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors publication-title: Cancer Res – volume: 22 start-page: 527 issue: 3 year: 2010 end-page: 532 ident: CR42 article-title: Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface publication-title: Cell Signal doi: 10.1016/j.cellsig.2009.11.007 – volume: 20 start-page: 349 issue: 5 year: 2005 end-page: 356 ident: CR1 article-title: The bone marrow vascular niche: home of HSC differentiation and mobilization publication-title: Physiology (Bethsda) doi: 10.1152/physiol.00025.2005 – volume: 4 start-page: e05521 year: 2015 ident: CR20 article-title: Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1 publication-title: elife – volume: 7 start-page: 452 issue: 4 year: 2005 end-page: 464 ident: CR26 article-title: The role of pericytes in blood-vessel formation and maintenance publication-title: Neuro-Oncology doi: 10.1215/S1152851705000232 – volume: 109 start-page: 625 issue: 5 year: 2002 end-page: 637 ident: CR34 article-title: Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand publication-title: Cell doi: 10.1016/S0092-8674(02)00754-7 – volume: 13 start-page: 206 issue: 3 year: 2008 end-page: 220 ident: CR28 article-title: HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.01.034 – volume: 279 start-page: H817 issue: 2 year: 2000 end-page: H824 ident: CR37 article-title: Lack of hypoxic stimulation of VEGF secretion from neutrophils and platelets publication-title: Am J Physiol Heart Circ Physiol – volume: 121 start-page: 2157 issue: 6 year: 2011 end-page: 2159 ident: CR21 article-title: The yin, the yang, and the angiopoietin-1 publication-title: J Clin Invest doi: 10.1172/JCI58196 – volume: 98 start-page: 1289 issue: 5 year: 2001 end-page: 1297 ident: CR36 article-title: Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor publication-title: Blood doi: 10.1182/blood.V98.5.1289 – volume: 105 start-page: 2631 year: 2005 end-page: 2639 ident: CR3 article-title: Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche publication-title: Blood doi: 10.1182/blood-2004-06-2480 – volume: 7 start-page: e39796 issue: 7 year: 2012 ident: CR23 article-title: Autocrine role of angiopoietins during megakaryocytic differentiation publication-title: PLoS One doi: 10.1371/journal.pone.0039796 – volume: 380 start-page: 525 issue: 2 year: 2016 end-page: 533 ident: CR5 article-title: Targeting the angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.09.035 – volume: 118 start-page: 149 year: 2004 end-page: 161 ident: CR18 article-title: Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche publication-title: Cell doi: 10.1016/j.cell.2004.07.004 – volume: 13 start-page: 206 issue: 2 year: 2016 end-page: 214 ident: CR14 article-title: Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward publication-title: Cancer Biol Med doi: 10.20892/j.issn.2095-3941.2015.0070 – volume: 48 start-page: 50 issue: 1 year: 2013 end-page: 55 ident: CR17 article-title: Higher angiopoietin-2 and VEGF levels predict shorter EFS and increased non-relapse mortality after pediatric hematopoietic SCT publication-title: Bone Marrow Transplant doi: 10.1038/bmt.2012.101 – volume: 99 start-page: 11205 issue: 17 year: 2002 end-page: 11210 ident: CR29 article-title: Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.172161899 – volume: 13 start-page: 616 issue: 8 year: 2012 end-page: 623 ident: CR24 article-title: Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation publication-title: J Zhejiang Univ Sci B doi: 10.1631/jzus.B1201004 – volume: 359 start-page: 843 issue: 6398 year: 1992 end-page: 845 ident: CR13 article-title: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis publication-title: Nature doi: 10.1038/359843a0 – volume: 284 start-page: 1994 issue: 5422 year: 1999 end-page: 1998 ident: CR45 article-title: Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF publication-title: Science doi: 10.1126/science.284.5422.1994 – volume: 92 start-page: 6 issue: 6 year: 2003 end-page: 6 ident: CR25 article-title: The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 publication-title: Circ Res doi: 10.1161/01.RES.0000063422.38690.DC – volume: 92 start-page: 1255 issue: 9 year: 2013 end-page: 1262 ident: CR7 article-title: The kinetics and apoptotic profile of circulating endothelial cells in autologous hematopoietic stem cell transplantation in patients with lymphoproliferative disorders publication-title: Ann Hematol doi: 10.1007/s00277-013-1759-4 – volume: 44-46 start-page: 94 year: 2015 end-page: 112 ident: CR32 article-title: Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature publication-title: Matrix Biol doi: 10.1016/j.matbio.2015.04.004 – volume: 272 start-page: 60 issue: 5258 year: 1996 end-page: 66 ident: CR35 article-title: Lymphocyte homing and homeostasis publication-title: Science doi: 10.1126/science.272.5258.60 – volume: 79 start-page: 574 issue: 10 year: 2000 end-page: 577 ident: CR9 article-title: Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma publication-title: Ann Hematol doi: 10.1007/s002770000236 – volume: 8 start-page: 2011 issue: 5 year: 2016 end-page: 2021 ident: CR19 article-title: Angiopoietin-1 facilitates recovery of hematopoiesis in radiated mice publication-title: Am J Transl Res – volume: 83 start-page: 1154 issue: 9 year: 2000 end-page: 1160 ident: CR46 article-title: Expression and function of angiopoietin-1 in breast cancer publication-title: Br J Cancer doi: 10.1054/bjoc.2000.1437 – volume: 359 start-page: 843 issue: 6398 year: 1992 ident: 3133_CR13 publication-title: Nature doi: 10.1038/359843a0 – volume: 121 start-page: 2157 issue: 6 year: 2011 ident: 3133_CR21 publication-title: J Clin Invest doi: 10.1172/JCI58196 – volume: 164 start-page: 204 year: 2016 ident: 3133_CR10 publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2016.06.001 – volume: 13 start-page: 206 issue: 2 year: 2016 ident: 3133_CR14 publication-title: Cancer Biol Med doi: 10.20892/j.issn.2095-3941.2015.0070 – volume: 4 start-page: e05521 year: 2015 ident: 3133_CR20 publication-title: elife doi: 10.7554/eLife.05521 – volume: 118 start-page: 771 issue: Pt 4 year: 2005 ident: 3133_CR43 publication-title: J Cell Sci doi: 10.1242/jcs.01653 – volume: 63 start-page: 3370 issue: 12 year: 2003 ident: 3133_CR47 publication-title: Cancer Res – volume: 79 start-page: 574 issue: 10 year: 2000 ident: 3133_CR9 publication-title: Ann Hematol doi: 10.1007/s002770000236 – volume: 2 start-page: a006502 issue: 7 year: 2012 ident: 3133_CR15 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006502 – volume: 90 start-page: 469 issue: 6 year: 2013 ident: 3133_CR39 publication-title: Eur J Haematol doi: 10.1111/ejh.12109 – volume: 13 start-page: 206 issue: 3 year: 2008 ident: 3133_CR28 publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.01.034 – volume: 17 start-page: 1359 issue: 11 year: 2011 ident: 3133_CR33 publication-title: Nat Med doi: 10.1038/nm.2537 – volume: 121 start-page: 1969 issue: 5 year: 2011 ident: 3133_CR30 publication-title: J Clin Invest doi: 10.1172/JCI44562 – volume: 2015 start-page: 786790 year: 2015 ident: 3133_CR8 publication-title: Dis Markers doi: 10.1155/2015/786790 – volume: 272 start-page: 60 issue: 5258 year: 1996 ident: 3133_CR35 publication-title: Science doi: 10.1126/science.272.5258.60 – volume: 12 start-page: 605 issue: 2 year: 2016 ident: 3133_CR11 publication-title: J Cancer Res Ther doi: 10.4103/0973-1482.146086 – volume: 48 start-page: 50 issue: 1 year: 2013 ident: 3133_CR17 publication-title: Bone Marrow Transplant doi: 10.1038/bmt.2012.101 – volume: 109 start-page: 625 issue: 5 year: 2002 ident: 3133_CR34 publication-title: Cell doi: 10.1016/S0092-8674(02)00754-7 – volume: 18 start-page: 976 issue: 5 year: 2004 ident: 3133_CR31 publication-title: Leukemia doi: 10.1038/sj.leu.2403331 – volume: 38 start-page: 149 issue: 2 year: 2006 ident: 3133_CR40 publication-title: Bone Marrow Transplant doi: 10.1038/sj.bmt.1705410 – volume: 99 start-page: 11205 issue: 17 year: 2002 ident: 3133_CR29 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.172161899 – volume: 116 start-page: 45 issue: 1 year: 2015 ident: 3133_CR44 publication-title: J Cell Biochem doi: 10.1002/jcb.24941 – volume: 102 start-page: 199 issue: 2 year: 2000 ident: 3133_CR22 publication-title: Cell doi: 10.1016/S0092-8674(00)00025-8 – volume: 98 start-page: 1289 issue: 5 year: 2001 ident: 3133_CR36 publication-title: Blood doi: 10.1182/blood.V98.5.1289 – volume: 7 start-page: e30758 issue: 2 year: 2012 ident: 3133_CR38 publication-title: PLoS One doi: 10.1371/journal.pone.0030758 – volume: 99 start-page: 679 issue: 6 year: 2012 ident: 3133_CR4 publication-title: Int J Hematol doi: 10.1007/s12185-014-1583-1 – volume: 20 start-page: 1335 issue: 9 year: 2014 ident: 3133_CR27 publication-title: Biol Blood Marrow Transplant doi: 10.1016/j.bbmt.2014.04.030 – volume: 8 start-page: 2011 issue: 5 year: 2016 ident: 3133_CR19 publication-title: Am J Transl Res – volume: 22 start-page: 527 issue: 3 year: 2010 ident: 3133_CR42 publication-title: Cell Signal doi: 10.1016/j.cellsig.2009.11.007 – volume: 92 start-page: 1255 issue: 9 year: 2013 ident: 3133_CR7 publication-title: Ann Hematol doi: 10.1007/s00277-013-1759-4 – volume: 7 start-page: e39796 issue: 7 year: 2012 ident: 3133_CR23 publication-title: PLoS One doi: 10.1371/journal.pone.0039796 – volume: 83 start-page: 1154 issue: 9 year: 2000 ident: 3133_CR46 publication-title: Br J Cancer doi: 10.1054/bjoc.2000.1437 – volume: 279 start-page: H817 issue: 2 year: 2000 ident: 3133_CR37 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.2000.279.2.H817 – volume: 105 start-page: 2631 year: 2005 ident: 3133_CR3 publication-title: Blood doi: 10.1182/blood-2004-06-2480 – volume: 10 start-page: e0119857 issue: 3 year: 2015 ident: 3133_CR12 publication-title: PLoS One doi: 10.1371/journal.pone.0119857 – volume: 92 start-page: 6 issue: 6 year: 2003 ident: 3133_CR25 publication-title: Circ Res doi: 10.1161/01.RES.0000063422.38690.DC – volume: 7 start-page: 452 issue: 4 year: 2005 ident: 3133_CR26 publication-title: Neuro-Oncology doi: 10.1215/S1152851705000232 – volume: 5 start-page: 434 issue: 4 year: 1999 ident: 3133_CR2 publication-title: Nat Med doi: 10.1038/7434 – volume: 3 start-page: 26 year: 2016 ident: 3133_CR6 publication-title: Stem Cell Investig doi: 10.21037/sci.2016.06.07 – volume: 19 start-page: 512 issue: 4 year: 2011 ident: 3133_CR16 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.02.005 – volume: 284 start-page: 1994 issue: 5422 year: 1999 ident: 3133_CR45 publication-title: Science doi: 10.1126/science.284.5422.1994 – volume: 13 start-page: 616 issue: 8 year: 2012 ident: 3133_CR24 publication-title: J Zhejiang Univ Sci B doi: 10.1631/jzus.B1201004 – volume: 20 start-page: 349 issue: 5 year: 2005 ident: 3133_CR1 publication-title: Physiology (Bethsda) doi: 10.1152/physiol.00025.2005 – volume: 380 start-page: 525 issue: 2 year: 2016 ident: 3133_CR5 publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.09.035 – volume: 44-46 start-page: 94 year: 2015 ident: 3133_CR32 publication-title: Matrix Biol doi: 10.1016/j.matbio.2015.04.004 – volume: 118 start-page: 149 year: 2004 ident: 3133_CR18 publication-title: Cell doi: 10.1016/j.cell.2004.07.004 – volume: 193 start-page: 1005 issue: 9 year: 2001 ident: 3133_CR41 publication-title: J Exp Med doi: 10.1084/jem.193.9.1005 |
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