VEGF, ANGPT1, ANGPT2, and MMP-9 expression in the autologous hematopoietic stem cell transplantation and its impact on the time to engraftment

As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at ex...

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Vydáno v:Annals of hematology Ročník 96; číslo 12; s. 2103 - 2112
Hlavní autoři: Nowicki, Mateusz, Wierzbowska, Agnieszka, Małachowski, Roman, Robak, Tadeusz, Grzybowska-Izydorczyk, Olga, Pluta, Agnieszka, Szmigielska-Kapłon, Anna
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2017
Springer Nature B.V
Témata:
Adult
Aged
Angiopoietin-1 - biosynthesis
Angiopoietin-2 - biosynthesis
Bone marrow
Cytokines
Female
Gene Expression Regulation, Neoplastic
Hematologic Neoplasms - blood
Hematologic Neoplasms - therapy
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma - blood
Lymphoma - therapy
Male
Matrix Metalloproteinase 9 - biosynthesis
Medicine
Medicine & Public Health
Middle Aged
Multiple Myeloma - blood
Multiple Myeloma - therapy
Neoplasm Proteins - biosynthesis
Oncology
Original Article
Stem cell transplantation
Stem cells
Transplants & implants
Vascular Endothelial Growth Factor A - biosynthesis
Engraftment
Angiopoietin
MMP-9
VEGF
Hematopoietic stem cell transplantation (HSCT)
ISSN:0939-5555, 1432-0584, 1432-0584
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Shrnutí:As a site of complicated interactions among cytokines, bone marrow niche has been the subject of many scientific studies, mainly in the context of the proteins influencing damage or recovery of endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplantation day (0) and 7 (+7), 14 (+14), and 21 (+21) days after HSCT. The cytokine levels were evaluated by ELISA method. Our study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. As opposite to ANGPT1, negative correlation between ANGPT2 level on day +7 after HSCT and the time to hematological recovery was noticed. Our study suggests that investigated cytokines are an important part of bone marrow environment and significantly influence the time to engraftment after HSCT.
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ISSN:0939-5555
1432-0584
1432-0584
DOI:10.1007/s00277-017-3133-4