Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency

Nuclear reprogramming efficiency has been shown to be highly variable among different types of somatic cells and different individuals, yet the underlying mechanism remains largely unknown. Several studies have shown that reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) requi...

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Bibliographic Details
Published in:	Stem cells and development Vol. 26; no. 3; p. 166
Main Authors:	Zhou, Yan, Al-Saaidi, Rasha Abdelkadhem, Fernandez-Guerra, Paula, Freude, Kristine K, Olsen, Rikke Katrine Jentoft, Jensen, Uffe Birk, Gregersen, Niels, Hyttel, Poul, Bolund, Lars, Aagaard, Lars, Bross, Peter, Luo, Yonglun
Format:	Journal Article
Language:	English
Published:	United States 01.02.2017
Subjects:	Adolescent Cell Respiration Cellular Reprogramming Child Child, Preschool Dermis - cytology Energy Metabolism Female Fibroblasts - metabolism Gene Editing Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Infant, Newborn Male Middle Aged Mitochondria - metabolism Reproducibility of Results nuclear reprogramming induced pluripotent stem cells mitochondrial spare respiratory capacity reprogramming efficiency oxidative phosphorylation
ISSN:	1557-8534, 1557-8534
Online Access:	Get more information
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