Fibromyalgia Pathogenesis and Treatment Options Update

This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatolo...

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Bibliographic Details
Published in:Current pain and headache reports Vol. 20; no. 4; p. 25
Main Authors: Chinn, Steven, Caldwell, William, Gritsenko, Karina
Format: Journal Article
Language:English
Published: New York Springer US 01.04.2016
Springer Nature B.V
Subjects:
Antidepressants
Fibromyalgia
Fibromyalgia - diagnosis
Fibromyalgia - physiopathology
Fibromyalgia - therapy
Humans
Internal Medicine
Medicine
Medicine & Public Health
Other Pain (N Vadivelu and A Kaye
Pain Management - methods
Pain Medicine
Pathogenesis
Risk Factors
Section Editors
Topical Collection on Other Pain
Fibromyalgia, pathogenesis
Central sensitivity syndrome
Fibromyalgia
Fibromyalgia, sleep disturbance
Fibromyalgia, acupuncture
Fibromyalgia, massage
Fibromyalgia, treatment
ISSN:1531-3433, 1534-3081, 1534-3081
Online Access:Get full text
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Summary:This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.
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ISSN:1531-3433
1534-3081
1534-3081
DOI:10.1007/s11916-016-0556-x