Fibromyalgia Pathogenesis and Treatment Options Update

This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatolo...

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Veröffentlicht in:	Current pain and headache reports Jg. 20; H. 4; S. 25
Hauptverfasser:	Chinn, Steven, Caldwell, William, Gritsenko, Karina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.04.2016 Springer Nature B.V
Schlagworte:	Antidepressants Fibromyalgia Fibromyalgia - diagnosis Fibromyalgia - physiopathology Fibromyalgia - therapy Humans Internal Medicine Medicine Medicine & Public Health Other Pain (N Vadivelu and A Kaye Pain Management - methods Pain Medicine Pathogenesis Risk Factors Section Editors Topical Collection on Other Pain Fibromyalgia, pathogenesis Central sensitivity syndrome Fibromyalgia Fibromyalgia, sleep disturbance Fibromyalgia, acupuncture Fibromyalgia, massage Fibromyalgia, treatment
ISSN:	1531-3433, 1534-3081, 1534-3081
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Abstract	This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.
AbstractList	This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed. This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.
ArticleNumber	25
Author	Caldwell, William Gritsenko, Karina Chinn, Steven
Author_xml	– sequence: 1 givenname: Steven surname: Chinn fullname: Chinn, Steven organization: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine – sequence: 2 givenname: William surname: Caldwell fullname: Caldwell, William organization: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine – sequence: 3 givenname: Karina surname: Gritsenko fullname: Gritsenko, Karina email: KGRITSEN@montefiore.org organization: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26922414$$D View this record in MEDLINE/PubMed
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SubjectTerms	Antidepressants Fibromyalgia Fibromyalgia - diagnosis Fibromyalgia - physiopathology Fibromyalgia - therapy Humans Internal Medicine Medicine Medicine & Public Health Other Pain (N Vadivelu and A Kaye Pain Management - methods Pain Medicine Pathogenesis Risk Factors Section Editors Topical Collection on Other Pain
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Title	Fibromyalgia Pathogenesis and Treatment Options Update
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