Two scenarios for overcoming drug resistance by co-targeting

Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of...

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Veröffentlicht in:	International journal of bioinformatics research and applications Jg. 11; H. 1; S. 72
Hauptverfasser:	Taheri, Golnaz, Ayati, Marzieh, Wong, Limsoon, Eslahchi, Changiz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland 2015
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - metabolism Computer Simulation Drug Design Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - physiology Models, Biological Protein Interaction Mapping - methods Signal Transduction - drug effects Signal Transduction - physiology protein protein interaction balanced bipartitioning E coli pathogens C jejuni bioinformatics PPI networks drug targets essential pathways drug resistance co–targeting
ISSN:	1744-5485
Online-Zugang:	Weitere Angaben
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