New Developments in Non-allergen-specific Therapy for the Treatment of Food Allergy

Purpose of Review The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatme...

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Vydáno v:Current allergy and asthma reports Ročník 20; číslo 1; s. 3
Hlavní autoři: Long, Andrew, Borro, Matteo, Sampath, Vanitha, Chinthrajah, R. Sharon
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.01.2020
Springer Nature B.V
Témata:
Allergology
Food allergies
Food Allergy (E Kim
Immunotherapy
Labeling
Medicine
Medicine & Public Health
Monoclonal antibodies
Section Editor
Topical Collection on Food Allergy
Omalizumab
Food allergy
Dupilumab
Immunotherapy
Biologics
Atopy
ISSN:1529-7322, 1534-6315, 1534-6315
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Shrnutí:Purpose of Review The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of durability of desensitization. Additionally, it is allergen-specific, and in those allergic to multiple allergens, the length and cost of treatment are further increased. In this review, we summarize recent developments in novel non-allergen-specific treatments for food allergy. Recent Findings A number of monoclonal antibodies that block IgE or specific pro-allergenic cytokines or their receptors have shown promise in clinical trials for food allergy. Summary The insight we have gained through the use of one drug for the treatment of an atopic disease is quickly being translated to other atopic diseases, including food allergy. The future for food allergy treatment with biologics looks bright.
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ISSN:1529-7322
1534-6315
1534-6315
DOI:10.1007/s11882-020-0897-8