An in vitro and in vivo Comparison of the Effect of Stevia rebaudiana Extracts on Different Caries-Related Variables: A Randomized Controlled Trial Pilot Study

The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers ri...

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Veröffentlicht in:Caries research Jg. 48; H. 1; S. 19 - 23
Hauptverfasser: Brambilla, E., Cagetti, M.G., Ionescu, A., Campus, G., Lingström, P.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel, Switzerland S. Karger AG 01.01.2014
Schlagworte:
2-YEAR
Adult
Bacterial Load - drug effects
Bacteriological Techniques
Biofilms - drug effects
Caries
Coloring Agents
Dental Caries - microbiology
Dental Plaque - physiopathology
DENTAL-CARIES
Diterpenes, Kaurane - pharmacology
Female
Follow-Up Studies
Glucosides - pharmacology
Humans
Hydrogen-Ion Concentration
INTENSE NATURAL SWEETENERS
Male
Mouthwashes - pharmacology
Odontologi
Odontology
Pilot Projects
Plant Extracts - pharmacology
PLAQUE-PH
Rebaudioside A
RISK
Short Communication
Spectrophotometry - methods
Stevia
Stevioside
Streptococcus mutans - drug effects
Streptococcus mutans - growth & development
SUCROSE
Sucrose - pharmacology
Sweetening Agents - pharmacology
SWEETNESS
Tetrazolium Salts
Thiazoles
Young Adult
Stevioside
Caries
Rebaudioside A
Plaque pH
ISSN:0008-6568, 1421-976X, 1421-976X
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Zusammenfassung:The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers rinsed for 1 min with each solutions, and plaque pH was measured at 7 time points after each rinse. Higher in vitro S. mutans biofilm formation was observed in sucrose solution (p < 0.01). After 5, 10, 15 and 30 min, the sucrose in vivo rinse produced a statistically significantly lower pH value compared to the Stevia extracts (F = 99.45, p < 0.01).Stevia extracts can be considered nonacidogenic.
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ISSN:0008-6568
1421-976X
1421-976X
DOI:10.1159/000351650