An in vitro and in vivo Comparison of the Effect of Stevia rebaudiana Extracts on Different Caries-Related Variables: A Randomized Controlled Trial Pilot Study

The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers ri...

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Vydáno v:	Caries research Ročník 48; číslo 1; s. 19 - 23
Hlavní autoři:	Brambilla, E., Cagetti, M.G., Ionescu, A., Campus, G., Lingström, P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel, Switzerland S. Karger AG 01.01.2014
Témata:	2-YEAR Adult Bacterial Load - drug effects Bacteriological Techniques Biofilms - drug effects Caries Coloring Agents Dental Caries - microbiology Dental Plaque - physiopathology DENTAL-CARIES Diterpenes, Kaurane - pharmacology Female Follow-Up Studies Glucosides - pharmacology Humans Hydrogen-Ion Concentration INTENSE NATURAL SWEETENERS Male Mouthwashes - pharmacology Odontologi Odontology Pilot Projects Plant Extracts - pharmacology PLAQUE-PH Rebaudioside A RISK Short Communication Spectrophotometry - methods Stevia Stevioside Streptococcus mutans - drug effects Streptococcus mutans - growth & development SUCROSE Sucrose - pharmacology Sweetening Agents - pharmacology SWEETNESS Tetrazolium Salts Thiazoles Young Adult Stevioside Caries Rebaudioside A Plaque pH
ISSN:	0008-6568, 1421-976X, 1421-976X
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Shrnutí:	The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers rinsed for 1 min with each solutions, and plaque pH was measured at 7 time points after each rinse. Higher in vitro S. mutans biofilm formation was observed in sucrose solution (p < 0.01). After 5, 10, 15 and 30 min, the sucrose in vivo rinse produced a statistically significantly lower pH value compared to the Stevia extracts (F = 99.45, p < 0.01).Stevia extracts can be considered nonacidogenic.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0008-6568 1421-976X 1421-976X
DOI:	10.1159/000351650