Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non‐Surgical Periodontal Therapy: A Pilot Study

Background: The emergence of periodontal medicine has increased interest in defining the serologic profiles of inflammatory mediators in subjects with periodontitis. Thus, the aim of this pilot study is to evaluate the serum levels of tumor necrosis factor‐alpha (TNF‐α), interferon‐γ, and interleuki...

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Vydané v:Journal of periodontology (1970) Ročník 81; číslo 7; s. 1056 - 1063
Hlavní autori: Duarte, Poliana Mendes, da Rocha, Marcelo, Sampaio, Eduardo, Mestnik, Maria Josefa, Feres, Magda, Figueiredo, Luciene Cristina, Bastos, Marta Ferreira, Faveri, Marcelo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Chicago, IL American Academy of Periodontology 01.07.2010
Predmet:
Adult
Aggressive Periodontitis - blood
Aggressive Periodontitis - therapy
Biological and medical sciences
Chronic Periodontitis - blood
Chronic Periodontitis - therapy
Cytokines
Cytokines - blood
Dental Plaque - classification
Dental Plaque - therapy
Dental Prophylaxis
Dental Scaling
enzyme‐linked immunosorbent assay
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Follow-Up Studies
Gingival Hemorrhage - classification
Gingival Hemorrhage - therapy
Humans
Inflammation Mediators - blood
Interferon-gamma - blood
Interleukin-17 - blood
Interleukin-23 - blood
Interleukin-4 - blood
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Periodontal Attachment Loss - classification
Periodontal Attachment Loss - therapy
Periodontal Index
Periodontal Pocket - classification
Periodontal Pocket - therapy
periodontitis
Pilot Projects
Root Planing
serum
Tumor Necrosis Factor-alpha - analysis
Young Adult
Human
Cytokines
Stomatology
Cytokine
Dentistry
Generalized
root planing
Tooth root
Chronic
Periodontal disease
Treatment
Periodontitis
Surgery
enzyme-linked immunosorbent assay
Serum
ELISA assay
ISSN:0022-3492, 1943-3670, 1943-3670
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Shrnutí:Background: The emergence of periodontal medicine has increased interest in defining the serologic profiles of inflammatory mediators in subjects with periodontitis. Thus, the aim of this pilot study is to evaluate the serum levels of tumor necrosis factor‐alpha (TNF‐α), interferon‐γ, and interleukin (IL)‐4, ‐17, and ‐23 in subjects with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) before and after non‐surgical periodontal therapy. Methods: Cytokines were measured by enzyme‐linked immunosorbent assay in serum samples taken from 42 systemically healthy subjects divided according to periodontal status into subjects with GAgP (n = 14) and GCP (n = 14) and periodontally healthy (PH) subjects (n = 14). In addition, the levels of cytokines were reassessed at 6 months after periodontal therapy in the periodontitis groups. Clinical parameters were also evaluated at baseline and 6 months post‐therapy. Results: After therapy, both periodontitis groups demonstrated a significant improvement in clinical periodontal status (P <0.05). At baseline, concentrations of TNF‐α (P = 0.0006) and IL‐17 (P = 0.02) were significantly higher in the GAgP group compared to the other groups. There was a significant decrease in serum concentrations of TNF‐α (P = 0.03) and IL‐17 (P = 0.04) at 6 months post‐therapy in the GAgP group (P <0.05). The concentration of TNF‐α remained elevated in the GAgP group compared to the PH group at 6 months post‐therapy (P = 0.04). Conclusions: Subjects with GAgP presented higher levels of TNF‐α and IL‐17 than subjects with GCP and PH subjects. In addition, although the serum levels of these cytokines improved significantly as a result of periodontal therapy, the levels of TNF‐α remained higher in subjects with GAgP compared to PH subjects.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0022-3492
1943-3670
1943-3670
DOI:10.1902/jop.2010.090732