Merkel cell polyomavirus DNA sequences in the blood of healthy population of Pakistan

This study aimed at detecting and quantifying Merkel cell polyomavirus (MCPyV) viral loads in the peripheral blood of healthy Pakistani individuals. A total of 221 whole blood samples obtained from healthy individuals were examined by qPCR. MCPyV was detected in the peripheral blood of 31.2% healthy...

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Veröffentlicht in:Future microbiology Jg. 14; H. 7; S. 599 - 608
Hauptverfasser: Shahzad, Naveed, Hussain, Iqra, Gilani, Usman S, Tayyeb, Asima, Aslam, Muhammad A, Khurshid, Muhammad, Hassan, Umair, Tasneem, Fareeda, Umer, Muhammd, Rashid, Naeem
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Future Medicine Ltd 01.05.2019
Schlagworte:
Age groups
Antigens
Blood & organ donations
Blood cells
Deoxyribonucleic acid
DNA
Genetic testing
Hepatitis
Immunocompetence
Immunocompetent individuals
Infections
MCPyV
Nucleotide sequence
Pakistan
Peripheral blood
Population
Punjab
qPCR
Skin cancer
Tumors
Urine
Viruses
Pakistan
Punjab
qPCR
Pakistan
MCPyV
Immunocompetent individuals
ISSN:1746-0913, 1746-0921, 1746-0921
Online-Zugang:Volltext
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Zusammenfassung:This study aimed at detecting and quantifying Merkel cell polyomavirus (MCPyV) viral loads in the peripheral blood of healthy Pakistani individuals. A total of 221 whole blood samples obtained from healthy individuals were examined by qPCR. MCPyV was detected in the peripheral blood of 31.2% healthy individuals. The rate of MCPyV positivity decreased from young (36%), to middle (33.7%) and elder (25.3%) age groups. Our data revealed higher prevalence of MCPyV in women (43.93%) than men (25.80%). The MCPyV viral load was calculated in the range of 0.06 -11 copies/ng of isolated DNA. The MCPyV viral load increased from young (median = 3.35) to elder (median = 5.66) age groups. The MCPyV circulate at a higher frequency by residing dormant in certain blood cells, which might act as potential vehicles for the spread of MCPyV infection among general population.
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ISSN:1746-0913
1746-0921
1746-0921
DOI:10.2217/fmb-2018-0314