Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples

The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared usin...

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Bibliographic Details
Published in:	PloS one Vol. 14; no. 1; p. e0210905
Main Authors:	Morgat, Clément, Schollhammer, Romain, Macgrogan, Gaétan, Barthe, Nicole, Vélasco, Valérie, Vimont, Delphine, Cazeau, Anne-Laure, Fernandez, Philippe, Hindié, Elif
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2019 Public Library of Science (PLoS)
Subjects:	Binding Binding sites Biology and Life Sciences Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Cancer Cancer therapies Chemotherapy Computed tomography ErbB-2 protein Estrogen receptors Estrogens Female Fluorine isotopes Fluorodeoxyglucose F18 - pharmacokinetics Gallium Radioisotopes - pharmacokinetics Gastrin Gastrin-releasing peptide Hospitals Humans Immunohistochemistry Lutetium Lymph nodes Lymphatic Metastasis - diagnostic imaging Lymphatic system Medical diagnosis Medical imaging Medical treatment Medicine and Health Sciences Metastases Metastasis Nodes Nuclear medicine Oligopeptides - pharmacokinetics Overexpression Patients Peptides Positron emission tomography Positron Emission Tomography Computed Tomography Progesterone Prostate cancer Radiation therapy Radioisotopes Radiopharmaceuticals - pharmacokinetics Receptor, ErbB-2 - metabolism Receptors, Bombesin - antagonists & inhibitors Receptors, Bombesin - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Research and Analysis Methods Retrospective Studies Studies Surgery Tumors France
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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