Febuxostat–p-Toluenesulfonic Acid Multi-Component Crystal: Characterization, Crystal Growth and Elucidation of the Salt/Co-Crystal Nature

The multi-component solid form of febuxostat (FEB) with p-toluenesulfonic acid was synthesized by solvent-drop grinding and cooling-evaporative crystallization and characterized by powder X-ray diffraction (XRPD), thermogravimetry (TGA), differential scanning calorimetry (DSC), and infrared spectros...

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Bibliographic Details
Published in:	Crystals (Basel) Vol. 13; no. 5; p. 836
Main Authors:	Ungur, Doriana T., Santiso-Quinones, Gustavo, Pop, Mihaela M., Tamas, Tudor L., Guguta, Carmen, Stam, Danny, Mija, Alice, Iordache, Coca A.
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 18.05.2023
Subjects:	Aging Basicity Bioavailability Cooling Crystal growth Crystal structure Crystallization Crystals Dissolution Evaporative cooling febuxostat Fourier transforms FT-IR High temperature Infrared spectroscopy p-toluenesulfonic acid Pharmaceutical industry Pharmacokinetics Relative humidity Rheumatism salt/co-crystal SC-XRD Solvents Thermogravimetry Uric acid X ray powder diffraction
ISSN:	2073-4352, 2073-4352
Online Access:	Get full text
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