Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response

The live attenuated yellow fever virus (YFV) 17D vaccine provides a good model to study immune responses to an acute viral infection in humans. We studied the temporal dynamics, composition, and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell respons...

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Veröffentlicht in:The Journal of immunology (1950) Jg. 190; H. 5; S. 2150
Hauptverfasser: Blom, Kim, Braun, Monika, Ivarsson, Martin A, Gonzalez, Veronica D, Falconer, Karolin, Moll, Markus, Ljunggren, Hans-Gustaf, Michaëlsson, Jakob, Sandberg, Johan K
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.03.2013
Schlagworte:
Adolescent
Adult
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
CD4-Positive T-Lymphocytes - virology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
CD8-Positive T-Lymphocytes - virology
Cytokines - biosynthesis
Cytokines - immunology
Histocompatibility Testing
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Immunologic Memory
Immunophenotyping
Middle Aged
Time Factors
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Yellow Fever - immunology
Yellow Fever - pathology
Yellow Fever - prevention & control
Yellow Fever - virology
Yellow Fever Vaccine - administration & dosage
Yellow Fever Vaccine - immunology
Yellow fever virus - immunology
ISSN:1550-6606, 1550-6606
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Zusammenfassung:The live attenuated yellow fever virus (YFV) 17D vaccine provides a good model to study immune responses to an acute viral infection in humans. We studied the temporal dynamics, composition, and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell response was broad and complex; it was composed of dominant responses that persisted into the memory population, as well as of transient subdominant responses that were not detected at the memory stage. Furthermore, HLA-A2- and HLA-B7-restricted YFV epitope-specific effector cells predominantly displayed a CD45RA(-)CCR7(-)PD-1(+)CD27(high) phenotype, which transitioned into a CD45RA(+)CCR7(-)PD-1(-)CD27(low) memory population phenotype. The functional profile of the YFV-specific CD8 T cell response changed in composition as it matured from an effector- to a memory-type response, and it tended to become less polyfunctional during the course of this transition. Interestingly, activation of CD4 T cells, as well as FOXP3(+) T regulatory cells, in response to YFV vaccination preceded the kinetics of the CD8 T cell response. The present results contribute to our understanding of how immunodominance patterns develop, as well as the phenotypic and functional characteristics of the primary human T cell response to a viral infection as it evolves and matures into memory.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1550-6606
1550-6606
DOI:10.4049/jimmunol.1202234